{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:08:28Z","timestamp":1758820108745},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,6,7]],"date-time":"2010-06-07T00:00:00Z","timestamp":1275868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>Taga T, Itoh E, Noda Y, Kato H, Maruo Y, Takano T, Ohta S, Takeuchi Y, Kumaki S. Successful unrelated umbilical cord blood cell transplantation without conditioning for a neonate with severe combined immunodeficiency.\u2028Pediatr Transplantation 2011: 15: E152\u2013E155. \u00a9 2010 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> A neonate was diagnosed as having SCID from his umbilical cord blood cells immediately after birth because his older brother had died of SCID eight months earlier. One locus\u2010mismatched unrelated umbilical cord blood cell transplantation without conditioning was performed at the age of 30\u2003days. The CD3\u2010positive cells were detected on day 14 post\u2010transplantation. There were no peri\u2010transplantation complications. Four yr after transplantation, the boy is in excellent condition and T and NK cell engraftments are complete. His peripheral B cells with a common gamma chain were not detected by flow cytometry, and he still needs IgG replacement; however, his IgM and IgA levels have gradually increased, and the dosage of IVIG per body weight has gradually decreased. We speculate that the very few B cells that proliferate from transplanted cord blood cells produce gamma globulin. Unrelated cord blood cell transplantation, even though mismatched, without conditioning would be a treatment option for neonates with severe combined immunodeficiency.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2010.01344.x","type":"journal-article","created":{"date-parts":[[2010,6,7]],"date-time":"2010-06-07T18:46:42Z","timestamp":1275936402000},"source":"Crossref","is-referenced-by-count":1,"title":["Successful unrelated umbilical cord blood cell transplantation without conditioning for a neonate with severe combined immunodeficiency"],"prefix":"10.1111","volume":"15","author":[{"given":"Takashi","family":"Taga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisuke","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyo","family":"Noda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Maruo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Takano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Kumaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,17]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00223.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.4049\/jimmunol.153.3.1310","article-title":"Impairment of ligand binding and growth signaling of mutant IL\u20102 receptor gamma\u2010chains in patients with X\u2010linked severe combined immunodeficiency","volume":"153","author":"Ishi N","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70199-9"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.07.049"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.3.872"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902183400703"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026463900925"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-177923"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1001\/jama.295.5.508","article-title":"Bone marrow transplantation for combined immune deficiency","volume":"295","author":"Grunebaum E","year":"2006","journal-title":"JAMA"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0960"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705054"},{"key":"e_1_2_7_13_2","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1182\/blood.V94.8.2923.420k44_2923_2930","article-title":"Long\u2010term chimerism and B cell function after bone marrow transplantation in patients with severe combined immunodeficiency with B cells: A single center study of 22 patients","volume":"94","author":"Haddad E","year":"1999","journal-title":"Blood"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3046.2010.01344.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3046.2010.01344.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T02:46:52Z","timestamp":1698720412000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3046.2010.01344.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,17]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1111\/j.1399-3046.2010.01344.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3046.2010.01344.x","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,17]]}}}