{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:23:45Z","timestamp":1768400625754,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,3,9]],"date-time":"2011-03-09T00:00:00Z","timestamp":1299628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Shetty AK, Ross GA, Pranikoff T, Gubareva LV, Sechrist C, Guirand DM, Abramson J, Lin J\u2010J. Oseltamivir\u2010resistant 2009 H1N1 influenza pneumonia during therapy in a renal transplant recipient.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The emergence of oseltamivir\u2010resistant 2009 H1N1 influenza virus (conferred by the H275Y substitution in NA) during therapy or prophylaxis in immunocompromised patients is a serious concern. The optimal therapy for immunosuppressed patients with oseltamivir\u2010resistant 2009 H1N1 influenza virus is unknown and few options exist. We report a 10\u2010yr\u2010old recipient of kidney transplant who was hospitalized with oseltamivir\u2010resistant 2009 H1N1 influenza pneumonia complicated by severe respiratory failure, ARDS, and renal failure requiring institution of ECMO and CRRT. On presentation, treatment with oseltamivir (second course) and broad\u2010spectrum antibiotics was initiated. Immunosuppressive agents were stopped on hospital day (d) 2. On hospital d 7, given his critical status, immunocompromised state, and difficulty in obtaining intravenous zanamivir, after obtaining ethical approval and parental consent, he was treated with intravenous peramivir (through an Emergency Investigational New Drug Application) for two\u2003wk. He tolerated the regimen well and his clinical status improved gradually. Several factors may have contributed to virus clearance and survival including recovery of the immune system, aggressive critical care support, and administration of peramivir. Ongoing surveillance is essential to monitor how oseltamivir\u2010resistant H275Y mutant viruses may evolve in the future.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2011.01489.x","type":"journal-article","created":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T03:39:28Z","timestamp":1299728368000},"source":"Crossref","is-referenced-by-count":17,"title":["Oseltamivir\u2010resistant 2009 H1N1 influenza pneumonia during therapy in a renal transplant recipient"],"prefix":"10.1111","volume":"16","author":[{"given":"Avinash K.","family":"Shetty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Pranikoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa V.","family":"Gubareva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Sechrist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek M.","family":"Guirand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Abramson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen\u2010Jar","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,9]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0588"},{"key":"e_1_2_8_3_2","first-page":"433","article-title":"Drug susceptibility of swine\u2010origin influenza A (H1N1) viruses, April 2009","volume":"58","author":"Centers for Disease Control and Prevention (CDC)","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_4_2","unstructured":"WorldHealthOrganization(WHO).Weekly Update on Oseltamivir Resistance to Influenza A (H1N1) 2009 Viruses. 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