{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T21:01:38Z","timestamp":1774990898011,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,23]],"date-time":"2011-10-23T00:00:00Z","timestamp":1319328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>Richmond ME, Hsu DT, Mosca RS, Chen J, Quaegebeur JM, Addonizio LJ, Lamour JM. Outcomes in pediatric cardiac transplantation with a positive HLA cross\u2010match. \u2028Pediatr Transplantation 2012: 16: 29\u201335. \u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Previous studies have shown poor outcomes in pediatric heart transplant recipients with a high PRA or a positive direct donor\u2013recipient cross\u2010match. This study describes outcomes in patients with a positive cross\u2010match at a large pediatric program. Pediatric heart transplant patients at a large single center between January 1993 and July 2009 were reviewed; those with cross\u2010match data were analyzed. Cross\u2010match data were available in 242\/262 (92.4%) patients. Indications for transplant were cardiomyopathy (58%), CHD (32%), and retransplant (7%). PRA was \u226510% in 31\/213 (14.6%) patients. A retrospective cross\u2010match was positive in 17\/31 (55%) patients with PRA \u226510% and 0\/182 with PRA &lt;10%. In positive cross\u2010match patients, rejection frequency in the first year post\u2010transplant was higher than negative cross\u2010match patients (1.69 vs. 0.96 episodes\/pt year, p\u2003=\u20030.014). There was no difference in rejection frequency after the first year post\u2010transplant (0.18 vs. 0.12 episodes\/pt year, p\u2003=\u20030.14). Overall survival was not significantly different between the groups with a median follow\u2010up time of 4.5\u2003yr. Heart transplantation in patients with a positive cross\u2010match may result in good medium\u2010term survival but a higher frequency of early rejection. Further investigation is warranted to define which patients with a positive cross\u2010match will do poorly.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2011.01555.x","type":"journal-article","created":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T04:05:46Z","timestamp":1319429146000},"page":"29-35","source":"Crossref","is-referenced-by-count":14,"title":["Outcomes in pediatric cardiac transplantation with a positive HLA cross\u2010match"],"prefix":"10.1111","volume":"16","author":[{"given":"Marc E.","family":"Richmond","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphne T.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph 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