{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:10:52Z","timestamp":1771297852972,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T00:00:00Z","timestamp":1318809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>Feingold B, Zheng J, Law YM, Morrow WR, Hoffman TM, Schechtman KB, Dipchand AI, Canter CE and the Pediatric Heart Transplant Study Investigators. Risk factors for late renal dysfunction after pediatric heart transplantation: A multi\u2010institutional study.\u2028Pediatr Transplantation 2011: 15: 699\u2013705. \u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Renal dysfunction is a major determinant of outcome after HTx. Using a large, multi\u2010institutional database, we sought to identify factors associated with late renal dysfunction after pediatric HTx. All patients in the PHTS database with eGFR \u226560\u2003mL\/min\/1.73\u2003m<jats:sup>2<\/jats:sup> at one\u2003yr post\u2010HTx (n\u2003=\u2003812) were analyzed by Cox regression for association with risk factors for eGFR &lt;60\u2003mL\/min\/1.73\u2003m<jats:sup>2<\/jats:sup> at &gt;1\u2003yr after HTx. Freedom from late renal dysfunction was 71% and 57% at five and 10\u2003yr. Multivariate risk factors for late renal dysfunction were earlier era of HTx (HR 1.84; p\u2003&lt;\u20030.001), black race (HR 1.42; p\u2003=\u20030.048), rejection with hemodynamic compromise in the first year after HTx (HR 1.74; p\u2003=\u20030.038), and lowest quartile eGFR at one\u2003yr post\u2010HTx (HR 1.83; p\u2003&lt;\u20030.001). Renal function at HTx was not associated with onset of late renal dysfunction. Eleven patients (1.4%) required chronic dialysis and\/or renal transplant during median follow\u2010up of 4.1\u2003yr (1.5\u201312.6). Late renal dysfunction is common after pediatric HTx, with blacks at increased risk. Decreased eGFR at one\u2003yr post\u2010HTx, but not at HTx, predicts onset of late renal dysfunction. Future research on strategies to minimize late renal dysfunction after pediatric HTx may be of greatest benefit if focused on these subgroups.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2011.01564.x","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T12:07:40Z","timestamp":1318853260000},"page":"699-705","source":"Crossref","is-referenced-by-count":50,"title":["Risk factors for late renal dysfunction after pediatric heart transplantation: A multi\u2010institutional study"],"prefix":"10.1111","volume":"15","author":[{"given":"Brian","family":"Feingold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuk M.","family":"Law","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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