{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:32:32Z","timestamp":1774963952948,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T00:00:00Z","timestamp":1319760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>Bonatti HJR, Axt J, Hunter EB, Lott SL, Frangoul H, Gillis L, Correa H, Kelly B. Castleman disease in a pediatric liver transplant recipient: A case report and literature review. \u2028Pediatr Transplantation 2011. \u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Castleman disease is a rare hematologic disorder, closely linked to the HHV\u20108, and most commonly observed in immunocompromised individuals. Thirteen months following a liver transplant for CPS\u20101 defect, a 15\u2010month\u2010old boy presented with fevers, anemia, and growth retardation. Abdominal CT scan showed splenomegaly and generalized lymphadenopathy. Histology of chest wall lymph nodes revealed a mixed CD3+ T\u2010cell and CD20+ B\u2010cell population with atretic germinal centers consistent with multicentric Castleman disease. Qualitative DNA PCR detected HHV\u20108 in the resected lymph node and in the blood, supporting the diagnosis. Immunosuppression was tapered, and he was transitioned from tacrolimus to sirolimus. His graft function remained stable, and repeat imaging showed regression of the lymphadenopathy. The child is living one\u2003yr after Castleman disease diagnosis with a well\u2010functioning graft. Castleman disease is a potential complication of solid organ transplant and HHV\u20108 infection. Reduction in immunosuppression and switch to sirolimus may be an effective strategy to treat this condition.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2011.01570.x","type":"journal-article","created":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T04:23:18Z","timestamp":1319775798000},"source":"Crossref","is-referenced-by-count":10,"title":["Castleman disease in a pediatric liver transplant recipient: A case report and literature review"],"prefix":"10.1111","volume":"16","author":[{"given":"Hugo J. R.","family":"Bonatti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Axt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen Bailey","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Louise","family":"Lott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haydar","family":"Frangoul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynette","family":"Gillis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hernan","family":"Correa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beau","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05311.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3181a9d4d3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860410002752"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000190204"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02702.x"},{"key":"e_1_2_5_7_2","first-page":"313","article-title":"[HHV\u20108 infection in renal transplantation]","volume":"22","author":"Lebbe C","year":"2001","journal-title":"Nephrologie"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.00028.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.03.144"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00288-8"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00263-3"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2008.05.004"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.03.059"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2003.00098.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-66-783-264"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328339018c"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2010.01.011"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015678312153"},{"issue":"1","key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"S410","DOI":"10.1007\/s001470050373","article-title":"HHV8 in renal transplant recipients","volume":"13","author":"Diociaiuti A","year":"2000","journal-title":"Transpl Int"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199911000-00010"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.06.085"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190290011994"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2006.00430.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2010.06.012"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181b15d56"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2010.02.012"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.03.051"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03366.x"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1086\/588821"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3046.2011.01570.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3046.2011.01570.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T15:14:16Z","timestamp":1698678856000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3046.2011.01570.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,28]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1399-3046.2011.01570.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3046.2011.01570.x","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,28]]}}}