{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:44:23Z","timestamp":1761101063642},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,11,8]],"date-time":"2011-11-08T00:00:00Z","timestamp":1320710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>Czubkowski P, Paw\u0142owska J, Jankowska I, Teisseyre M, Kami\u0144ska D, Markiewicz M, Ry\u017cko J. Successful sirolimus rescue in tacrolimus\u2010induced thrombotic microangiopathy after living\u2010related liver transplantation. Pediatr Transplantation 2011: 00: 000\u2013000. \u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> TMA is a rare complication of tacrolimus. Disruption of endothelial cells, platelet aggregation, and intravascular mechanical fragmentation of red cells are core mechanisms of injury; however, exact pathways of toxicity are not clear. The clinical presentation may vary but TMA is a potentially life\u2010threatening condition usually demanding aggressive treatment. We present the case of TMA in a child after living\u2010related liver transplantation (LRLTx) on tacrolimus\u2010based immunosuppressive regiment successfully converted to sirolimus.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2011.01601.x","type":"journal-article","created":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T02:03:55Z","timestamp":1320804235000},"source":"Crossref","is-referenced-by-count":10,"title":["Successful sirolimus rescue in tacrolimus\u2010induced thrombotic microangiopathy after living\u2010related liver transplantation"],"prefix":"10.1111","volume":"16","author":[{"given":"Piotr","family":"Czubkowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Paw\u0142owska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Jankowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miko\u0142aj","family":"Teisseyre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Kami\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Markiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zef","family":"Ry\u017cko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703710"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00282.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199608)52:4<310::AID-AJH11>3.0.CO;2-H"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(96)90468-0"},{"key":"e_1_2_6_6_2","first-page":"243","article-title":"Microangiopathic haemolytic anemia and thrombocytopenia following lung volume reduction surgery in a single lung transplant recipient on maintenance tacrolimus (FK506) therapy","volume":"8","author":"Reid DW","year":"2003","journal-title":"Respiratory"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.12.016"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21253"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03355.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811263392202"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.03.010"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lts.2003.09.021"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i14.1848"},{"key":"e_1_2_6_14_2","first-page":"282","article-title":"Tacrolimus\u2010related posttransplant lymphoproliferative disorder presenting as autoimmune hemolytic anemia","volume":"120","author":"Digiuseppe JA","year":"1996","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2009.07.004"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01047.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22861"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02482.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.07.011"},{"key":"e_1_2_6_20_2","first-page":"203","article-title":"Rituximab for managing relapsing or refractory patients with idiopathic thrombotic thrombocytopenic purpura\u2010haemolytic uraemic syndrome","volume":"8","author":"Caramazza D","year":"2010","journal-title":"Blood Transfus"},{"key":"e_1_2_6_21_2","first-page":"67","article-title":"FK506\u2010associated thrombotic microangiopathy: Report of two cases and review of the literature","volume":"27","author":"Trimarchi HM","year":"1999","journal-title":"Transplantation"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.07.117"},{"key":"e_1_2_6_23_2","first-page":"80","article-title":"Thrombotic microangiopathy in living\u2010donor liver transplantation","volume":"27","author":"Tamura S","year":"2005","journal-title":"Transplantation"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-006-3394-3"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3046.2011.01601.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3046.2011.01601.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T15:14:05Z","timestamp":1698678845000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3046.2011.01601.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,8]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1399-3046.2011.01601.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3046.2011.01601.x","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,8]]}}}