{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:04:01Z","timestamp":1791857041472,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T00:00:00Z","timestamp":1322092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Upadhyay K, Midgley L, Moudgil A. Safety and efficacy of alemtuzumab in the treatment of late acute renal allograft rejection.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Safety and efficacy of alemtuzumab in the treatment of AR in children after renal transplantation is unknown. Five episodes of refractory late AR in three children (three episodes in patient 1 and a single episode in patients 2 and 3 occurring after 7\u201323\u2003months of transplantation) were treated with one dose of alemtuzumab as a rescue therapy. Four episodes (Banff IA\u2010IB) in patients 1 and 2 reversed fully or partially with alemtuzumab, whereas patient 3 with Banff IB\u2010IIA AR failed to respond. Patient 1 had recurrent AR 5, 13, and 15\u2003months later; first two episodes responded to retreatment with alemtuzumab, and the last episode was not treated causing allograft failure. Patient 2 had steroid\u2010responsive AR after two\u2003months and had a functioning allograft 25\u2003months later. A transient reduction in all lymphocyte subsets except natural killer cells occurred in all patients. Patient 3 (treated with steroids, Thymoglobulin<jats:sup>R<\/jats:sup>, intravenous immunoglobulin, and rituximab prior to alemtuzumab) suffered many bacterial infections during one\u2010yr period after therapy. However, symptomatic viral infections were not observed in any of the children. Treatment with alemtuzumab may prolong allograft survival in multidrug\u2010resistant AR but may not prevent recurrent AR in non\u2010adherent children.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2011.01615.x","type":"journal-article","created":{"date-parts":[[2011,11,25]],"date-time":"2011-11-25T03:30:55Z","timestamp":1322191855000},"page":"286-293","source":"Crossref","is-referenced-by-count":17,"title":["Safety and efficacy of alemtuzumab in the treatment of late acute renal allograft rejection"],"prefix":"10.1111","volume":"16","author":[{"given":"Kiran","family":"Upadhyay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Midgley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Moudgil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,24]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0869-z"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(99)00065-2"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.21"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2006.00561.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00087.x"},{"key":"e_1_2_7_7_2","unstructured":"North American Pediatric Renal Transplantation Cooperative Study (NAPRTCS) Annual report. 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