{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T20:15:26Z","timestamp":1784578526041,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,12,18]],"date-time":"2011-12-18T00:00:00Z","timestamp":1324166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Anastaze Stelle K, Belli DC, Parvex P, Girardin E, Giroud A, Wildhaber B, McLin VA. Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The aim of this study was to analyze the impact of TAC on medium term (three\u2010yr follow\u2010up) renal function in pediatric liver transplant (OLT) recipients. Glomerular and tubular indices were retrospectively analyzed in 24 consecutive OLT pediatric recipients on TAC. CrCl increased significantly each month post\u2010OLT (p\u2003=\u20030.003), with a trend toward significance between pre\u2010OLT and 36\u2003months (p\u2003=\u20030.17). There was no correlation between CrCl and TAC troughs (p\u2003=\u20030.783). Sixteen percent of patients had CrCl &lt;60\u2003mL\/min\/1.73\u2003m<jats:sup>2<\/jats:sup> pre\u2010OLT vs. none at 36\u2003months post\u2010OLT. TRP values were normal throughout the study. UPr\/Cr decreased insignificantly over time and correlated significantly with TAC trough levels (p\u2003=\u20030.031). UCa\/Cr values normalized by the third\u2010month post\u2010OLT, decreasing significantly over the time (p\u2003=\u20030.000) but did not correlate with TAC troughs. At three\u2003months post\u2010OLT, 65.2% of patients needed antihypertensive therapy, and no patients needed more than one antihypertensive treatment after one\u2003yr. Despite nephrotoxic side effects in the early postoperative phase, this study shows that 65.5% patients had a normal renal function by three\u2003yr post\u2010OLT. Tubular indices correlated with TAC trough levels.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2011.01625.x","type":"journal-article","created":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T02:58:43Z","timestamp":1324263523000},"page":"250-256","source":"Crossref","is-referenced-by-count":13,"title":["Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus"],"prefix":"10.1111","volume":"16","author":[{"given":"K.","family":"Anastaze Stelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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