{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:27:25Z","timestamp":1774330045781,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T00:00:00Z","timestamp":1330041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>Kathemann S, Lainka E, Baba HA, Hoyer PF, Gerner P. Gilbert\u2019s syndrome \u2013 a frequent cause of unconjugated hyperbilirubinemia in children after orthotopic liver transplantation. \u2028Pediatr Transplantation 2012: 16: 201\u2013204. \u00a9 2012 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Gilbert\u2019s syndrome is one major cause for unconjugated hyperbilirubinemia in healthy individuals with the prevalence being approximately 3.2\u20138.6%. It is caused by a mutation in the promoter region of the UGT1A1\u2010gene with a prolonged TAA\u2010repeat coding for the enzyme bilirubin UDP\u2010glucuronosyltransferase (A(TA)<jats:sub>7<\/jats:sub>TAA allele). After OLT, Gilbert\u2019s disease of the transplanted liver can cause unconjugated hyperbilirubinemia. Therefore, we looked for the presence of A(TA)<jats:sub>7<\/jats:sub>TAA alleles in pediatric liver transplant recipients with unconjugated hyperbilirubinemia. Laboratory results of 106 pediatric liver transplant recipients (aged 0\u201317\u2003yr) were evaluated for elevated total bilirubin over 2.0\u2003mg\/dL (conjugated bilirubin &lt;30%). In these patients, DNA of the liver graft was extracted from paraffin\u2010embedded liver biopsy samples formerly taken for diagnostic reasons. The DNA was analyzed for A(TA)<jats:sub>7<\/jats:sub>TAA alleles in the promoter region of the UGT1A1\u2010gene. In 4 of 106 pediatric liver transplant recipients we found unconjugated hyperbilirubinemia with total bilirubin above 2.0\u2003mg\/dL (conjugated bilirubin &lt;30%). The analysis of the promoter region of the UGT1A1\u2010gene of the liver grafts showed three homozygous A(TA)<jats:sub>7<\/jats:sub>TAA alleles (homozygous Gilbert\u2019s syndrome) and one heterozygous A(TA)<jats:sub>7<\/jats:sub>TAA allele (heterozygous Gilbert\u2019s syndrome). This study shows that pediatric liver transplant recipients with unconjugated hyperbilirubinemia are very likely to have received a liver graft from a donor with Gilbert\u2019s syndrome.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2012.01662.x","type":"journal-article","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T07:14:44Z","timestamp":1330067684000},"page":"201-204","source":"Crossref","is-referenced-by-count":9,"title":["Gilbert\u2019s syndrome \u2013 a frequent cause of unconjugated hyperbilirubinemia in children after orthotopic liver transplantation"],"prefix":"10.1111","volume":"16","author":[{"given":"Simone","family":"Kathemann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Lainka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo A.","family":"Baba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter F.","family":"Hoyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Gerner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,24]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1068222"},{"key":"e_1_2_8_3_2","first-page":"588","article-title":"The prevalence of isolated unconjugated hyperbilirubinaemia (Gilbert\u2019s syndrome) in subjects attending a health screening programme in Singapore","volume":"33","author":"Gwee KA","year":"1992","journal-title":"Singapore Med J"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197007232830403"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196906052802303"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.22.12128"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91273-8"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80272-3"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200005150-00024"},{"key":"e_1_2_8_10_2","unstructured":"QIAamp DNA Mini Kit and QIAamp DNA Blood Mini Kit 09\/2001:50\u201351."},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1520\/JFS14226J"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840150531"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.E0213"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840040618"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000226149.31117.e4"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.11.045"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3046.2012.01662.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3046.2012.01662.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T10:31:45Z","timestamp":1698661905000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3046.2012.01662.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,24]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1399-3046.2012.01662.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3046.2012.01662.x","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,24]]}}}