{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:01:23Z","timestamp":1772456483579,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,2,26]],"date-time":"2012-02-26T00:00:00Z","timestamp":1330214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Kawahara Y, Morimoto A, Masuzawa A, Ikeda T, Hayase T, Kashii Y, Nozaki Y, Kanai N, Momoi MY. Successful treatment with pulse cyclophosphamide of a steroid\u2010refractory hepatitic variant of liver acute graft\u2010vs.\u2010host disease in a child. \u2028Pediatr Transplantation 2012: 00: 000\u2013000. \u00a9 2012 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> A 13\u2010yr\u2010old boy with recurrent acute myeloid leukemia underwent HSCT using cells from an unrelated donor who matched all HLA antigens except one. Forty\u2010two days later, the patient developed a steroid\u2010refractory hepatitic variant of liver GVHD with peak ALT and T.Bil values of 1406\u2003mU\/mL and 10.4\u2003mg\/dL, respectively. He was successfully treated with pulse Cy (1000\u2003mg\/dose\u2003\u00d7\u2003one\u2003day) without a change in chimerism being observed or acquiring an infection. All immunosuppressant therapies could be discontinued 12\u2003months after HSCT. Two\u2003yr after HSCT, the patient remains in CR without chronic GVHD. This single case report suggests that pulse Cy may be a promising therapy for steroid\u2010refractory GVHD, especially hepatitic GVHD, but needs to be further tested in clinical trials.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2012.01664.x","type":"journal-article","created":{"date-parts":[[2012,2,27]],"date-time":"2012-02-27T02:36:11Z","timestamp":1330310171000},"source":"Crossref","is-referenced-by-count":6,"title":["Successful treatment with pulse cyclophosphamide of a steroid\u2010refractory hepatitic variant of liver acute graft\u2010vs.\u2010host disease in a 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