{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:52:36Z","timestamp":1765975956281},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T00:00:00Z","timestamp":1329955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Lin N\u2010C, Niu D\u2010M, Loong C\u2010C, Hsia C\u2010Y, Tsai H\u2010L, Yeh Y\u2010C, Tsou M\u2010Y, Liu C\u2010S. Liver transplantation for a patient with homocystinuria. \u2028Pediatr Transplantation 2012. \u00a9 2012 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> A 24\u2010yr\u2010old man was diagnosed with HCU during neonatal screening and remained on a pyridoxine, vitamin B12, folic acid, and betaine regimen with dietary methionine restriction for more than 10\u2003yr. He had normal mental development, marfanoid appearance, myopia because of lens dislocation, and recurrent ankle subluxation during adolescence. Thereafter, he was a poor adherent to the conventional diet\u2010restrictive therapy, and LT was considered when he developed hypertension and multiple infarctions over the right cerebellum early in the second decade of his life despite taking aspirin as a prophylaxis from 17\u2003yr of age. In November 2009, he received a deceased whole LT from a blood group compatible donor. Along with the success of the transplantation, he was completely disease free without dietary or nutritional control. To the best of our knowledge, this is the first case of LT intended to cure HCU, and with promising results. This case provides an insight into the role of LT for this congenital metabolic disease, for which the decision should be made by judging between the severity of the disease and the risk of the operation, as well as the life quality of the patient.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2012.01666.x","type":"journal-article","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T01:17:22Z","timestamp":1330046242000},"source":"Crossref","is-referenced-by-count":9,"title":["Liver transplantation for a patient with homocystinuria"],"prefix":"10.1111","volume":"16","author":[{"given":"Niang\u2010Cheng","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dau\u2010Min","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che\u2010Chuan","family":"Loong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Yuan","family":"Hsia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Lin","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Chen","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010Yung","family":"Tsou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin\u2010Su","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,23]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.37.195.505"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(62)90114-6"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.143.3613.1443"},{"key":"e_1_2_7_5_2","first-page":"1","article-title":"The natural history of homocystinuria due to cystathionine \u03b2\u2010synthase deficiency","volume":"37","author":"Mudd SH","year":"1985","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198308253090802"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2007.04.002"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9177-4"},{"key":"e_1_2_7_9_2","first-page":"1279","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"Mudd SH","year":"1995"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905133401915"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.09.015"},{"key":"e_1_2_7_12_2","first-page":"111","article-title":"Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis","volume":"56","author":"McCully KS","year":"1969","journal-title":"Am J Pathol"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/hq1201.100225"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005445132327"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01339.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2005.10.010"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9129-z"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3046.2012.01666.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3046.2012.01666.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:20:27Z","timestamp":1698657627000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3046.2012.01666.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,23]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1399-3046.2012.01666.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3046.2012.01666.x","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,23]]}}}