{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:46:03Z","timestamp":1782776763807,"version":"3.54.5"},"reference-count":2,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T00:00:00Z","timestamp":1336953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Hill AL, Maeda K, Bonham CA, Concepcion W. Pediatric combined heart\u2013liver transplantation performed <jats:italic>en bloc<\/jats:italic>: A single\u2010center experience.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Pediatric CHLT is rarely performed in transplant centers and even fewer are performed <jats:italic>en bloc<\/jats:italic>. In the hands of an experienced surgeon with the appropriate patient selection, CHLT performed <jats:italic>en bloc<\/jats:italic> may have several operative and immunologic benefits, thereby resulting in improved outcomes for the transplant recipient. A single\u2010institutional, retrospective review from 1\/1\/06 to 12\/31\/10 was conducted. Three pediatric patients with end\u2010stage heart and liver disease who were considered low immunologic risk were included. All were managed by the same surgeon with a herein\u2010described CHLT donor and recipient operation. Data were collected on patient and graft survival, rejection episodes, infectious complications, operative time, intraoperative transfusion requirements, and immunosuppression regimens. One\u2010yr patient and graft survival rates were 100%. No patients experienced antibody\u2010mediated or cell\u2010mediated rejection. No patients had postoperative infections, and all patients were free of opportunistic infections at one\u2010yr post\u2010transplant. All patients were maintained safely on steroid\u2010free immunosuppression. There were no intraoperative complications. In pediatric end\u2010stage heart and liver disease patients with low immunologic risk, it is reasonable to proceed with <jats:italic>en bloc<\/jats:italic> CHLT so long as there is an experienced surgeon to perform the case. This offers operative and immunologic advantages to the recipient while maintaining equivalent, if not improved, recipient and graft outcomes.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2012.01695.x","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T15:47:53Z","timestamp":1337010473000},"page":"392-397","source":"Crossref","is-referenced-by-count":52,"title":["Pediatric combined heart\u2013liver transplantation performed <i>en bloc<\/i>: A single\u2010center experience"],"prefix":"10.1111","volume":"16","author":[{"given":"Amy L.","family":"Hill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhide","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clark A.","family":"Bonham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldo","family":"Concepcion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,14]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.04.004"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91876-2"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3046.2012.01695.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3046.2012.01695.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T01:42:06Z","timestamp":1698630126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3046.2012.01695.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,14]]},"references-count":2,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1399-3046.2012.01695.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3046.2012.01695.x","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,14]]}}}