{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T06:45:21Z","timestamp":1698734721707},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T00:00:00Z","timestamp":1336089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Tangnararatchakit K, Tirapanich W, Anurathapan U, Tapaneya\u2010Olarn W, Pakakasama S, Jootar S, Slavin S, Hongeng S. Depletion of alloreactive T cells for tolerance induction in a recipient of kidney and hematopoietic stem cell transplantations.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The present case report represents a successful attempt to induce transplantation tolerance to organ allograft by combined administration of donor hematopoietic cells and kidney based on in vivo deletion of alloreactive host\u2010vs\u2010graft and graft\u2010vs\u2010host alloreactive T cells following non\u2010myeloablative conditioning. We were able to induce mixed and eventually full donor chimerism and tolerance of kidney allograft in a 15\u2010yr\u2010old male with ESRD after cisplatin treatment and autologous HSCT for mediastinal germ cell tumor. Our approach to induce tolerance was based on preferential depletion of alloreactive T cells induced by exposure to donor\u2019s alloantigens and administration of cyclophosphamide at day 2 and day 3 after stem cell infusion. Additional non\u2010specific immunosuppression as part of the conditioning included exposure to two fractions of TLI, treatment with alemtuzumab (monoclonal anti\u2010CD52) and short\u2010term conventional IS treatment to avoid early graft loss, because of request of IRB. Using this approach, with rapid tapering of all conventional IS treatment, the patient maintains good renal functions without evidence of both acute and chronic rejection for 32\u2003months off all medications.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2012.01701.x","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T06:51:41Z","timestamp":1336114301000},"source":"Crossref","is-referenced-by-count":0,"title":["Depletion of alloreactive T cells for tolerance induction in a recipient of kidney and hematopoietic stem cell 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