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Surgical management of stem cell transplantation\u2010related complications in children.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> HSCT is an established treatment option for some children with life\u2010threatening diseases, but complications remain a major cause of morbidity and mortality. This retrospective data analysis addresses the surgical issues of children with HSCT\u2010related complications. Between 2002 and 2008, HSCT was performed in 240 children for leukemias\/lymphomas (n=135), solid tumors (n=59), immunodeficiencies (n=20), lipid storage diseases (n=10), autoimmune diseases (n=9), and others (n=7). HSCT\u2010related complications requiring surgery occurred in 24 cases (10%) and most often in the leukemias\/lymphomas group (18\/24 cases): HC (cystoscopic irrigation, n=7), pulmonary aspergilloses (resection, n=7), bone necroses (core decompression, n=3), GvHD bowel (colostomy\/PEG, n=2), ICH (drainage, n=2), bilateral kidney abscess (nephrectomies\/renal transplantation, n=1), aspergillosis of the maxillary sinus (decompression, n=1), and post\u2010traumatic wound healing disorder (meshed skin transplantation, n=1). Survival was 50% in the group with surgery and 62% in the group without (p=0.275). Even though this difference was not statistically significant, surgical intervention should be encouraged in all cases to achieve favorable results.<\/jats:p>","DOI":"10.1111\/j.1399-3046.2012.01708.x","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T14:53:38Z","timestamp":1337007218000},"page":"471-479","source":"Crossref","is-referenced-by-count":9,"title":["Surgical management of stem cell transplantation\u2010related complications in children"],"prefix":"10.1111","volume":"16","author":[{"given":"Justus","family":"Lieber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Hauch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupert","family":"Handgretinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Blumenstock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven W.","family":"Warmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,14]]},"reference":[{"issue":"8","key":"e_1_2_8_2_2","first-page":"51","article-title":"Unrelated donor marrow transplantation in childhood: A report from the Associazione Italiana Ematologia e Oncologia Pediatrica (AIEOP) and the Gruppo Italiano per il Trapianto Midollo Osseo (GITMO)","volume":"87","author":"Dini G","year":"2002","journal-title":"Haematologica"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70252-5"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.08.031"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-942256"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3312"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.56"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22750"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000247038.43228.17"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2815"},{"key":"e_1_2_8_11_2","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1182\/blood.V91.4.1469","article-title":"Acute bleeding after bone marrow transplantation (BMT)\u2013 incidence and effect on survival. 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