{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T10:44:08Z","timestamp":1767523448031},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,8,4]],"date-time":"2006-08-04T00:00:00Z","timestamp":1154649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Abstract: <\/jats:bold>  <jats:italic>Nocardia<\/jats:italic> infection is a well\u2010recognized complication in renal transplant recipients and other immunocompromised hosts. It is mostly a primary pulmonary infection, which can disseminate to other organs in half of the cases. Nocardiosis is a life\u2010threatening infection. Therefore, an efficient long\u2010lasting treatment must be rapidly administered. We report 1 case of disseminated nocardiosis with pulmonary involvement, brain lesions, and bone lesions in a renal transplant patient, who was treated with stereotactic aspiration in association with high dose of trimethoprim\/sulfamethoxazole (TMP\/SMX) and imipenem, changed, after 3 weeks to moxifloxacin. First, clinical manifestations decreased after surgical drainage and combination therapy with the 2 antimicrobial agents, but later the patient developed a recurrence of brain lesions during treatment with quinolones. Consequently, the patient was again treated with TMP\/SMX and imipenem, after which the patient recovered. It is surprising that moxifloxacin was efficient <jats:italic>in vitro<\/jats:italic> and the antimicrobial concentration in the central nervous system was high, yet the nocardial abscess recurred under this therapy.<\/jats:p>","DOI":"10.1111\/j.1399-3062.2006.00130.x","type":"journal-article","created":{"date-parts":[[2006,8,5]],"date-time":"2006-08-05T01:16:59Z","timestamp":1154740619000},"page":"161-165","source":"Crossref","is-referenced-by-count":16,"title":["Intracranial <i>Nocardia<\/i> recurrence during fluorinated quinolones therapy"],"prefix":"10.1111","volume":"8","author":[{"given":"K.","family":"Dahan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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[French.]","volume":"25","author":"Canet S","year":"2004","journal-title":"Nephrologie"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050023"},{"key":"e_1_2_4_10_2","article-title":"First successful treatment of Nocardia farcinica brain abscess with moxifloxacin","author":"Fihman V","year":"2005","journal-title":"J Infect"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-8663(03)00248-0"},{"key":"e_1_2_4_12_2","first-page":"492","article-title":"Successful management of disseminated Nocardia transvalensis infection in a heart transplant recipient after development of sulfonamide resistance","volume":"22","author":"Lopez FA","year":"2003","journal-title":"case report and review"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2002.02006.x"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2002.01005.x"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(02)90265-1"},{"key":"e_1_2_4_16_2","first-page":"304","article-title":"Successful therapy combined with surgery for severe post\u2010transplant nocardiosis","volume":"14","author":"Kayacan SM","year":"2001","journal-title":"J Nephrol"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000045716"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.30.2.270"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.12.2013"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/24.1.39"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0732-8893(88)90025-9"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3062.2006.00130.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3062.2006.00130.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T14:01:53Z","timestamp":1696946513000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3062.2006.00130.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,4]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1399-3062.2006.00130.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3062.2006.00130.x","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,4]]}}}