{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:25:24Z","timestamp":1793424324112,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,8,4]],"date-time":"2006-08-04T00:00:00Z","timestamp":1154649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Abstract: Background.<\/jats:bold>Urinary tract infection is the most common form of bacterial infection encountered in a renal transplant recipient. Studies explaining the long\u2010term consequences of acute graft pyelonephritis (AGPN) are few.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold>A total of 1022 consecutive renal allograft recipients were studied retrospectively over a period of 10 years for evidence of AGPN. These patients were classified into two groups according to the presence or absence of at least one AGPN episode. Only culture\u2010proven infections were included in the study.<\/jats:p><jats:p><jats:bold>Result.<\/jats:bold>Of the 1022 renal transplant recipients, 169 patients (16.5%) developed AGPN. In the multivariate analysis with stepwise logistic regression, significant associations were observed between AGPN and placement of ureteric stent (odds ratio [OR]=4.6), urological malformations of native kidney (OR=2.1), cytomegalovirus (CMV) disease (OR=2.0), mycophenolate mofetil (MMF)\u2010based regimen (OR=1.9), and acute rejection episodes (OR=1.5). However, age&gt;40 years, female gender, induction therapy, anti\u2010CD3 treatment, and hyperglycemia did not show such an association. In comparison with the non\u2010AGPN group, these patients had a lower graft and patient survival (though it did not attain statistical significance). In the multivariate analysis using the Cox model for the entire study population, AGPN did not independently contribute to poor graft or patient survival.<\/jats:p><jats:p><jats:bold>Conclusion.<\/jats:bold>AGPN in the renal transplant setting is an ominous event, as these patients are also more prone to develop bacteremia, acute rejection, and CMV disease, which could then lead to poor graft and patient survival. Its association with MMF needs further clarification.<\/jats:p>","DOI":"10.1111\/j.1399-3062.2006.00148.x","type":"journal-article","created":{"date-parts":[[2006,8,5]],"date-time":"2006-08-05T01:16:59Z","timestamp":1154740619000},"page":"140-147","source":"Crossref","is-referenced-by-count":145,"title":["Acute graft pyelonephritis following renal transplantation"],"prefix":"10.1111","volume":"8","author":[{"given":"N.S.","family":"Kamath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.T.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Neelakantan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.G.","family":"Kirubakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.K.","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,4]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"518","article-title":"Chronic renal allograft rejection","volume":"49","author":"Massy ZA","year":"1996","journal-title":"immunologic and non-immunologic risk factors"},{"key":"e_1_2_8_3_2","first-page":"308","article-title":"Bacterial infection in renal homotransplant recipients","volume":"53","author":"Myerowitz RL","year":"1972","journal-title":"a study of fifty-three bacteremic episodes"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70381-0"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198309000-00007"},{"key":"e_1_2_8_6_2","first-page":"2110","article-title":"Urinary tract infection after renal transplantation under conventional therapy and cyclosporine","volume":"21","author":"Stuby U","year":"1989","journal-title":"Transplant Proc"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00323.x"},{"key":"e_1_2_8_8_2","first-page":"2593","article-title":"Renal transplantation using stents","volume":"27","author":"Bassiri A","year":"1995","journal-title":"Transplant Proc"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(75)90795-5"},{"key":"e_1_2_8_10_2","first-page":"881","article-title":"Insertion of a double pigtail ureteral stent for the prevention of urological complications in renal transplantation","volume":"156","author":"Benoit G","year":"1996","journal-title":"a prospective randomized study"},{"key":"e_1_2_8_11_2","first-page":"657","article-title":"Evaluation of the urological complications of living related renal transplantation at a single center during the last 10 years","volume":"164","author":"Kumar A","year":"2000","journal-title":"impact of the Double-J\u00ae stent"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000019927"},{"key":"e_1_2_8_13_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1399-0012.1998.tb01063.x","article-title":"Urinary tract infections following renal transplantation","volume":"12","author":"Takai K","year":"1998","journal-title":"Clin Transplant"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92152-9"},{"key":"e_1_2_8_15_2","first-page":"1597","volume-title":"Brenner & Rector's The Kidney","author":"Rubin RH","year":"1997"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91116-9"},{"key":"e_1_2_8_17_2","first-page":"367","article-title":"Cytomegalovirus infection in a seroendemic renal transplant population","volume":"84","author":"Rao M","year":"2000","journal-title":"a longitudinal study of virological markers"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2001.00026.x"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2003.00035.x"},{"key":"e_1_2_8_20_2","first-page":"638","article-title":"Mycophenolate mofetil in pediatric renal transplantation without induction therapy","volume":"71","author":"Staskewitz A","year":"2001","journal-title":"results after 12 months of treatment. German Pediatric Renal Transplantation Study Group"},{"key":"e_1_2_8_21_2","first-page":"80","article-title":"Mycophenolate mofetil in pediatric renal transplantation","volume":"9","author":"Ojogho O","year":"2005","journal-title":"non-induction vs. induction with basiliximab"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.08.015"},{"key":"e_1_2_8_23_2","first-page":"67","article-title":"Mycophenolic acid and brequinar, inhibitors of purine and pyrimidine synthesis, block the glycosylation of adhesion molecules","volume":"25","author":"Allison AC","year":"1993","journal-title":"Transplant Proc"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.41.020190.001555"},{"key":"e_1_2_8_25_2","first-page":"86","article-title":"Induction of immunity against human cytomegalovirus","volume":"71","author":"Bennekov T","year":"2004","journal-title":"Mt Sinai J Med"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3062.2006.00148.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3062.2006.00148.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T09:46:56Z","timestamp":1736502416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3062.2006.00148.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,4]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1399-3062.2006.00148.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3062.2006.00148.x","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,4]]}}}