{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:19:18Z","timestamp":1790864358815,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,9,6]],"date-time":"2010-09-06T00:00:00Z","timestamp":1283731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>\n                    G. Kantarci, Z. Eren, A. Demira\u011f, I. Dogan, F. \u00c7akalagaoglu, G. Yilmaz.\u2028JC virus\u2010associated nephropathy in a renal transplant recipient and comparative analysis of previous cases.\u2028Transpl Infect Dis 2011:\n                    <jats:bold>13:<\/jats:bold>\n                    89\u201392. All rights reserved\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Abstract:<\/jats:bold>\n                    We report JC virus (JCV)\u2010associated nephropathy in a renal allograft recipient and summarize the clinical and laboratory data of the 8 previous cases. A 28\u2010year\u2010old male renal allograft recipient received a preemptive transplant from his father. Six months later, a kidney biopsy was performed because of deterioration of allograft function. Biopsy revealed tubulointerstitial mononuclear infiltrates with normal glomeruli; on hematoxylin and eosin staining, basophilic nuclear inclusions were seen in the nucleus of tubular cells. Urinary cytology failed to demonstrate decoy cells, but polymerase chain reaction of a urinary sample was positive for JCV 3.15 \u00d7 10\n                    <jats:sup>10<\/jats:sup>\n                    \u2003copies\/mL. Additionally, polyomavirus (SV40) immunohistochemical staining was performed and was positive in the enlarged nuclei of tubular epithelial cells in the kidney biopsy sample. After the diagnosis of polyomavirus\u2010associated nephropathy (PVAN) was confirmed by kidney biopsy, immunosuppressive agents were reduced. Intravenous immunoglobulin was administered 5 times at a dose of 500\u2003mg\/kg every other 3 weeks. Two months after diagnosis, the serum creatinine became stable and urinary viral load of JCV was decreased. Because viruria was still present, tacrolimus was converted to sirolimus. Four months after immunosuppressive agent conversion from tacrolimus to sirolimus, the viruria had disappeared. Review of the literature and our case demonstrates that male gender, previous acute rejection episode, low incidence of JCV viremia, PVAN pattern B histology, and reducing immunosuppression are the diagnostic touchstones for PVAN due to JCV.\n                  <\/jats:p>","DOI":"10.1111\/j.1399-3062.2010.00567.x","type":"journal-article","created":{"date-parts":[[2010,9,7]],"date-time":"2010-09-07T19:09:41Z","timestamp":1283886581000},"page":"89-92","source":"Crossref","is-referenced-by-count":52,"title":["JC virus\u2010associated nephropathy in a renal transplant recipient and comparative analysis of previous cases"],"prefix":"10.1111","volume":"13","author":[{"given":"G.","family":"Kantarci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Eren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Demira\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"\u00c7akalagaoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,9,6]]},"reference":[{"issue":"7","key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1056\/NEJMoa020439","article-title":"Prospective study of polyomavirus type BK replication and nephropathy in renal\u2010transplant recipients","volume":"347","author":"Hirsch HH","year":"2002","journal-title":"N Engl J Med"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20037"},{"issue":"12","key":"e_1_2_6_4_2","first-page":"1245","article-title":"Polyomavirus disease in renal transplantation","volume":"36","author":"Drachenberg CB","year":"2005","journal-title":"review of pathological findings and diagnostic methods"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)91777-6"},{"key":"e_1_2_6_6_2","first-page":"54","volume-title":"Human Polyomaviruses: Molecular and Clinical Perspectives","author":"Imperiale M.","year":"2001"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000090749.42791.14"},{"issue":"3","key":"e_1_2_6_8_2","first-page":"323","article-title":"Polyomavirus BK versus JC replication and nephropathy in renal transplant recipients","volume":"84","author":"Drachenberg CB","year":"2007","journal-title":"a prospective evaluation"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20442"},{"issue":"3","key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/ndt\/gfn671","article-title":"Risk factors for polyoma virus nephropathy","volume":"24","author":"Prince O","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.03.040"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3062.2010.00567.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3062.2010.00567.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T01:27:06Z","timestamp":1698715626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3062.2010.00567.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,6]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1111\/j.1399-3062.2010.00567.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3062.2010.00567.x","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,6]]}}}