{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:49:39Z","timestamp":1761630579837},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,7]],"date-time":"2011-02-07T00:00:00Z","timestamp":1297036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>C. Rafat, S. Vimont, P.Y. Ancel, Y.C. Xu\u2010Dubois, L. Mesnard, N. Ouali, M. Denis, A. Vandewalle, E. Rondeau, A. Hertig. Ofloxacin: new applications for the prevention of urinary tract infections in renal graft recipients\u2028Transpl Infect Dis 2011: <jats:bold>13:<\/jats:bold> 344\u2013352. All rights reserved<\/jats:p><jats:p><jats:bold>Abstract: <\/jats:bold><jats:bold> Background. <\/jats:bold> Urinary tract infections (UTIs), the most common form of bacterial infection in kidney transplant recipients, recently have been demonstrated to be detrimental for long\u2010term graft outcome. Therefore, reinforcing antibiotic prophylaxis might be vital, in addition to basic hygiene recommendations, surgical care, and prophylaxis by trimethoprim\u2013sulfamethoxazole.<\/jats:p><jats:p><jats:bold>Methods. <\/jats:bold> In 2006, a <jats:italic>Legionella pneumophila<\/jats:italic> contamination of our department's water pipes meant that all the patients undergoing renal transplantation underwent a 1\u2010month regimen of ofloxacin (OFLO) (200\u2003mg every other day). We took this opportunity to measure the incidence of UTI, including acute pyelonephritis (APN), in 100 consecutive patients transplanted before (<jats:italic>n<\/jats:italic>=50) and after (<jats:italic>n<\/jats:italic>=50) this treatment decision was reached. We also studied the antimicrobial resistance profiles in our department and in the rest of the hospital.<\/jats:p><jats:p><jats:bold>Results. <\/jats:bold> No patient developed Legionnaire's disease. A dramatic decrease in the incidence of UTI (\u221263%) was also seen in patients undergoing OFLO treatment. Logistic regression analysis demonstrated that the use of OFLO was independently associated with a reduction in UTI (odd ratio [OR]=0.31%, 95% confidence interval [CI] 0.11\u20130.84, <jats:italic>P<\/jats:italic>=0.02) and APN (OR=0.21%, 95% CI 0.07\u20130.98, <jats:italic>P<\/jats:italic>=0.045). This protection was sustained during the whole first year post transplantation. As for resistance rates, we observed a decrease in the susceptibility of <jats:italic>Pseudomonas aeruginosa<\/jats:italic> to ciprofloxacin in our nephrology department, compared with that observed in the rest of the hospital. The incidence of multi\u2010resistant bacteria was stable.<\/jats:p><jats:p><jats:bold>Discussion. <\/jats:bold> Our unintentional extension of prophylactic antibiotherapy with OFLO gave rise to a dramatic decrease in the 1\u2010year incidence of UTI and APN in kidney recipients. Emergence of resistant strains is, however, a major concern.<\/jats:p>","DOI":"10.1111\/j.1399-3062.2011.00602.x","type":"journal-article","created":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T03:43:37Z","timestamp":1297136617000},"page":"344-352","source":"Crossref","is-referenced-by-count":17,"title":["Ofloxacin: new applications for the prevention of urinary tract infections in renal graft recipients"],"prefix":"10.1111","volume":"13","author":[{"given":"C.","family":"Rafat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Vimont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.Y.","family":"Ancel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.C.","family":"Xu\u2010Dubois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mesnard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ouali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Denis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vandewalle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Rondeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hertig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,7]]},"reference":[{"issue":"4","key":"e_1_2_6_2_2","first-page":"401","article-title":"Infectious complications after kidney transplantation","volume":"20","author":"Alangaden GJ","year":"2006","journal-title":"current epidemiology and associated risk factors"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0781"},{"issue":"1","key":"e_1_2_6_4_2","first-page":"24","article-title":"Causes of death in renal transplant recipients","volume":"88","author":"Reis MA","year":"1995","journal-title":"a study of 102 autopsies from 1968 to 1991"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.04.040"},{"issue":"2","key":"e_1_2_6_6_2","first-page":"230","article-title":"Urinary tract infections after renal transplantation","volume":"19","author":"Chuang P","year":"2005","journal-title":"a retrospective review at two US transplant centers"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01700.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00323.x"},{"issue":"8","key":"e_1_2_6_9_2","first-page":"1128","article-title":"Acute graft pyelonephritis","volume":"80","author":"Audard V","year":"2005","journal-title":"a potential cause of acute rejection in renal transplant"},{"issue":"6","key":"e_1_2_6_10_2","first-page":"360","article-title":"Infectious diseases in hospitalized renal transplant recipients","volume":"61","author":"Peterson PK","year":"1982","journal-title":"a prospective study of a complex and evolving problem"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.02.060"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199856050-00015"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01644096"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044097"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.2.215"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s150100070019"},{"issue":"2","key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1128\/AAC.40.2.503","article-title":"Emergence of fluoroquinolone\u2010resistant Escherichia coli in fecal flora of cancer patients receiving norfloxacin prophylaxis","volume":"40","author":"Carratala J","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"issue":"12","key":"e_1_2_6_18_2","first-page":"798","article-title":"Hospital characteristics associated with colonization of water systems by Legionella and risk of nosocomial Legionnaires' disease","volume":"20","author":"Kool JL","year":"1999","journal-title":"a cohort study of 15 hospitals"},{"issue":"6","key":"e_1_2_6_19_2","first-page":"368","article-title":"Hospital\u2010acquired legionellosis","volume":"2","author":"Sabria M","year":"2002","journal-title":"solutions for a preventable infection"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/516258"},{"issue":"7","key":"e_1_2_6_21_2","first-page":"291","article-title":"[Treatment of legionellosis with ofloxacin in kidney transplanted patients Lack of interaction with cyclosporin A]","volume":"20","author":"Wynckel A","year":"1991","journal-title":"Presse Med"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009347869"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46747-0"},{"issue":"6","key":"e_1_2_6_24_2","first-page":"2072","article-title":"Nosocomial outbreak due to a multiresistant strain of Pseudomonas aeruginosa P12","volume":"39","author":"Dubois V","year":"2001","journal-title":"efficacy of cefepime\u2013amikacin therapy and analysis of beta-lactam resistance"},{"issue":"8","key":"e_1_2_6_25_2","first-page":"2187","article-title":"Impact of n\u20106 polyunsaturated fatty acids on growth of multidrug\u2010resistant Pseudomonas aeruginosa","volume":"44","author":"Giamarellos\u2010Bourboulis EJ","year":"2000","journal-title":"interactions with amikacin and ceftazidime"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01196.x"},{"issue":"3","key":"e_1_2_6_27_2","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1128\/iai.34.3.920-929.1981","article-title":"Glycolipid receptors for uropathogenic Escherichia coli on human erythrocytes and uroepithelial cells","volume":"34","author":"Leffler H","year":"1981","journal-title":"Infect Immun"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.16.5898"},{"issue":"16","key":"e_1_2_6_29_2","first-page":"8829","article-title":"Bad bugs and beleaguered bladders","volume":"97","author":"Mulvey MA","year":"2000","journal-title":"interplay between uropathogenic Escherichia coli and innate host defenses"},{"issue":"3","key":"e_1_2_6_30_2","first-page":"375","article-title":"Recurrent urinary tract infections in infancy","volume":"185","author":"Jantunen ME","year":"2002","journal-title":"relapses or reinfections?"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1179\/joc.1999.11.5.357"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(01)00469-1"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(00)00353-8"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.1998.12.101"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2006.00148.x"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0805.010204"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02559.x"},{"issue":"3","key":"e_1_2_6_38_2","first-page":"159","article-title":"Extended\u2010spectrum beta\u2010lactamase\u2010producing Enterobacteriaceae","volume":"8","author":"Pitout JD","year":"2008","journal-title":"an emerging public-health concern"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1086\/382690"},{"issue":"3","key":"e_1_2_6_40_2","first-page":"443","article-title":"Epidemiology of hospital\u2010acquired infections in cirrhotic patients","volume":"127","author":"Campillo B","year":"2001","journal-title":"effect of carriage of methicillin-resistant Staphylococcus aureus and influence of previous antibiotic therapy and norfloxacin prophylaxis"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1086\/379709"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199404283301717"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3062.2011.00602.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3062.2011.00602.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T14:27:29Z","timestamp":1698762449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3062.2011.00602.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,7]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1111\/j.1399-3062.2011.00602.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3062.2011.00602.x","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,7]]}}}