{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:21:14Z","timestamp":1761895274076},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,5,27]],"date-time":"2011-05-27T00:00:00Z","timestamp":1306454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>J.E. Rogers, A. Cumpston, M. Newton, M. Craig. Onset and complications of varicella zoster reactivation in the autologous hematopoietic cell transplant population.\u2028Transpl Infect Dis 2011: <jats:bold>13:<\/jats:bold> 480\u2013484. All rights reserved<\/jats:p><jats:p><jats:bold>Background. <\/jats:bold> Varicella zoster virus (VZV) infections are a common complication in patients receiving autologous or allogeneic hematopoietic cell transplant (HCT). Recent guideline revisions suggest extending VZV prophylaxis to 1 year after autologous HCT. We retrospectively evaluated reactivation at our center, before implementation of extended acyclovir prophylaxis, to determine onset and outcome in the autologous HCT population.<\/jats:p><jats:p><jats:bold>Methods. <\/jats:bold> Inclusion criteria consisted of adult patients who received an autologous HCT\u2003 with documentation for at least 1 year post transplant. Those excluded from review were patients who received acyclovir prophylaxis for &gt;30 days post transplant or subsequently received an allogeneic transplant within 1 year. For patients in whom reactivation occurred, the severity of infection, the timing of onset, treatment of the reactivation, and any complications were recorded.<\/jats:p><jats:p><jats:bold>Results. <\/jats:bold> In the final analysis, 56 patients were assessed. Reactivation of zoster occurred in 16% of recipients with a median onset of 4.5 months post transplant. Complications that were observed include postherpetic neuralgia, severe pain, scarring, and motor weakness. Two patients required hospitalization for treatment, with 1 patient requiring 6 months of rehabilitation for motor weakness following the infection.<\/jats:p><jats:p><jats:bold>Conclusions. <\/jats:bold> Our study revealed a 16% incidence of VZV reactivation in our autologous HCT population. The onset of these occurrences ranged from 2 to 10 months post transplant, with significant VZV\u2010associated complications. We consider VZV reactivation a serious concern in the autologous transplant setting, requiring extended prophylaxis.<\/jats:p>","DOI":"10.1111\/j.1399-3062.2011.00655.x","type":"journal-article","created":{"date-parts":[[2011,5,27]],"date-time":"2011-05-27T06:46:25Z","timestamp":1306478785000},"page":"480-484","source":"Crossref","is-referenced-by-count":28,"title":["Onset and complications of varicella zoster reactivation in the autologous hematopoietic cell transplant population"],"prefix":"10.1111","volume":"13","author":[{"given":"J.E.","family":"Rogers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cumpston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703214"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/320157"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.4065\/84.3.274"},{"issue":"4","key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1182\/blood.V74.4.1424.1424","article-title":"Herpes zoster infection after autologous bone marrow transplantation","volume":"74","author":"Shuchter LM","year":"1989","journal-title":"Blood"},{"key":"e_1_2_6_6_2","article-title":"High incidence of herpes zoster in nonmyeloablative hematopoietic stem cell transplantation","author":"Su SH","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"e_1_2_6_7_2","unstructured":"National Comprehensive Cancer Network Inc.Prevention and treatment of cancer\u2010related infections version 1.2011. Available athttp:\/\/www.nccn.org\/professionals\/physician_gls\/PDF\/infections.pdf. Accessed 2011 May 9."},{"key":"e_1_2_6_8_2","first-page":"1","article-title":"Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients","volume":"49","author":"Dykewicz CA","year":"2000","journal-title":"MMWR Recomm Rep."},{"issue":"10","key":"e_1_2_6_9_2","first-page":"1143","article-title":"Guidelines for preventing infectious complications among hematopoietic cell transplant recipients","volume":"15","author":"Tomblyn M","year":"2009","journal-title":"a global perspective"},{"issue":"8","key":"e_1_2_6_10_2","first-page":"3071","article-title":"One year acyclovir prophylaxis for preventing varicella zoster virus disease after hematopoietic cell transplantation","volume":"110","author":"Erard V","year":"2007","journal-title":"no evidence of rebound varicella-zoster virus disease after drug discontinuation"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.99"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3062.2011.00655.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3062.2011.00655.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T17:40:06Z","timestamp":1698774006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3062.2011.00655.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,27]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1111\/j.1399-3062.2011.00655.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3062.2011.00655.x","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,27]]}}}