{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:20:05Z","timestamp":1784636405475,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T00:00:00Z","timestamp":1316995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract:<\/jats:title><jats:p>Post\u2010transplantation histoplasmosis may be acquired via inhalation, may result from endogenous reactivation, or may be derived from the allograft. The <jats:italic>Histoplasma<\/jats:italic> and <jats:italic>Aspergillus<\/jats:italic> enzyme\u2010linked immunoassays are increasingly being relied upon for rapid diagnosis of fungal infections, especially in immunocompromised patients. We describe 4 cases of solid organ transplant recipients who had histoplasmosis and a falsely positive <jats:italic>Aspergillus<\/jats:italic> galactomannan (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) obtained from the serum or bronchoalveolar lavage (<jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content>) fluid. We also report our experience, testing for <jats:italic>Histoplasma<\/jats:italic> antigen (<jats:styled-content style=\"fixed-case\">Ag<\/jats:styled-content>) in specimens positive for <jats:italic>Aspergillus<\/jats:italic> <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>. From January 2007 through December 2010, of 2432 unique patients who had positive <jats:italic>Aspergillus<\/jats:italic> <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> tests, 514 (21%) were tested for <jats:italic>Histoplasma<\/jats:italic> <jats:styled-content style=\"fixed-case\">Ag<\/jats:styled-content>, and 27 were found to be positive. Most specimens that tested positive for both <jats:italic>Aspergillus<\/jats:italic> and <jats:italic>Histoplasma<\/jats:italic> were obtained by <jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content>. False\u2010positive tests for <jats:italic>Aspergillus<\/jats:italic> <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> can occur in immunosuppressed patients who have histoplasmosis, and may obscure the correct diagnosis.<\/jats:p>","DOI":"10.1111\/j.1399-3062.2011.00675.x","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T00:57:41Z","timestamp":1317171461000},"page":"213-217","source":"Crossref","is-referenced-by-count":65,"title":["False\u2010positive <i>Aspergillus<\/i> galactomannan assay in solid organ transplant recipients with histoplasmosis"],"prefix":"10.1111","volume":"14","author":[{"given":"P.","family":"Vergidis","sequence":"first","affiliation":[{"name":"Department of Medicine and William J. von Liebig Transplant Center Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.C.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Medicine and William J. von Liebig Transplant Center Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R.","family":"Kaul","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Michigan Health Systems Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"Kauffman","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Michigan Health Systems Ann Arbor Michigan USA"},{"name":"Veterans Affairs Ann Arbor Healthcare System Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.G.","family":"Freifeld","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Nebraska Medical Center Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.C.","family":"Slagle","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Illinois 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