{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T08:17:28Z","timestamp":1788682648498,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,16]],"date-time":"2012-02-16T00:00:00Z","timestamp":1329350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Parainfluenza virus (<jats:styled-content style=\"fixed-case\">PIV<\/jats:styled-content>) infections can cause serious respiratory infections and death in immunocompromised patients. No antiviral agents have proven efficacy against <jats:styled-content style=\"fixed-case\">PIV<\/jats:styled-content>, and therapy generally consists of supportive care. <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>181, a novel sialidase fusion protein that temporarily disables airway epithelial <jats:styled-content style=\"fixed-case\">PIV<\/jats:styled-content> receptors by enzymatic removal of sialic acid moieties, has been shown to inhibit infection with <jats:styled-content style=\"fixed-case\">PIV<\/jats:styled-content> strains <jats:italic>in vitro<\/jats:italic> and in an animal model. We describe here the clinical course of 2 immunocompromised patients with <jats:styled-content style=\"fixed-case\">PIV<\/jats:styled-content>\u20103 infection, one with a history of lung transplantation and the other neutropenic after autologous hematopoietic stem cell transplantation for multiple myeloma. Both patients had substantial clinical improvement in respiratory and systemic symptoms after a 5\u2010day <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>181 treatment course, although the clinical improvement in the autologous stem cell transplantation patient also paralleled neutrophil engraftment.<\/jats:p>","DOI":"10.1111\/j.1399-3062.2012.00718.x","type":"journal-article","created":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T04:02:28Z","timestamp":1329451348000},"page":"427-433","source":"Crossref","is-referenced-by-count":60,"title":["Clinical potential of <scp>DAS<\/scp>181 for treatment of parainfluenza\u20103 infections in transplant recipients"],"prefix":"10.1111","volume":"14","author":[{"given":"B.B.","family":"Guzm\u00e1n\u2010Suarez","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Brigham and Women's Hospital Boston Massachusetts USA"},{"name":"Dana\u2010Farber Cancer Institute Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.W.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Brigham and Women's Hospital Boston Massachusetts USA"},{"name":"Dana\u2010Farber Cancer Institute Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.T.","family":"Gilmore","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Brigham and Women's Hospital Boston Massachusetts USA"},{"name":"Dana\u2010Farber Cancer Institute Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vocca","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Brigham and Women's Hospital Boston Massachusetts USA"},{"name":"Dana\u2010Farber Cancer Institute Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Moss","sequence":"additional","affiliation":[{"name":"NexBio, Inc. 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