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A literature search was performed with regard to reported cases of cryptosporidiosis in <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight renal, 1 liver, and 1 lung transplant recipient were diagnosed with cryptosporidiosis at median 46.0\u00a0months (interquartile range [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>] 25.2\u201362.8) following <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>. Symptoms existed for a median 14\u00a0days (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 10.5\u201314.8) before diagnosis. For the 9 patients receiving tacrolimus (<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>), mean <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> levels increased from 6.3\u00a0\u00b1\u00a01.1 to 21.3\u00a0\u00b1\u00a09.2\u00a0ng\/mL (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0007) and median serum creatinine increased temporarily from 1.3 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 1.1\u20131.7) to 2.4 (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 2.0\u20134.6) mg\/dL (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.008). By comparison, 8 <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> recipients (6 kidney, 2 liver) hospitalized with community\u2010onset <jats:styled-content style=\"fixed-case\">CDI<\/jats:styled-content> had a mean <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> level of 10.8\u00a0\u00b1\u00a02.8\u00a0ng\/dL during disease compared with 9.2\u00a0\u00b1\u00a02.3\u00a0ng\/mL at baseline (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.07) and had no change in median creatinine. All patients recovered from <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ryptosporidium<\/jats:italic> enteritis after receiving various chemotherapeutic regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cryptosporidiosis should be recognized as an important cause of diarrhea after <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> and is associated with elevated <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> levels and acute kidney injury. Increased <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> levels may reflect altered drug metabolism in the small intestine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-3062.2012.00719.x","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T05:10:25Z","timestamp":1329714625000},"page":"635-648","source":"Crossref","is-referenced-by-count":54,"title":["<i>Cryptosporidium<\/i> enteritis in solid organ transplant recipients: multicenter retrospective evaluation of 10 cases reveals an association with elevated tacrolimus concentrations"],"prefix":"10.1111","volume":"14","author":[{"given":"H.","family":"Bonatti","sequence":"first","affiliation":[{"name":"Department of Surgery University of Virginia Health System Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.F.","family":"Barroso II","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and International Health Department of Medicine University of Virginia Health System Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.G.","family":"Sawyer","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Virginia Health System Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.N.","family":"Kotton","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.D.","family":"Sifri","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and International Health Department of Medicine University of Virginia Health System Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2007.00251.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9770-z"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20500"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2004.00073.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn693"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2007.00530.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2007.00255.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2004.00040.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2007.00237.x"},{"key":"e_1_2_6_11_1","first-page":"3547","volume-title":"Principles and Practice of Infectious Diseases","author":"White AC","year":"2010"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(96)10018-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199407213310304"},{"issue":"36","key":"e_1_2_6_14_1","first-page":"989","article-title":"Communitywide cryptosporidiosis outbreak\u2013Utah, 2007","volume":"57","year":"2008","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-5-199603010-00001"},{"issue":"5","key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"E13","DOI":"10.2807\/esm.12.05.00711-en","article-title":"Cryptosporidiosis surveillance and water\u2010borne outbreaks in Europe","volume":"12","author":"Semenza JC","year":"2007","journal-title":"Euro Surveill"},{"issue":"6","key":"e_1_2_6_17_1","first-page":"1","article-title":"Cryptosporidiosis surveillance \u2010 United States, 2006\u20102008","volume":"59","author":"Yoder JS","year":"2010","journal-title":"MMWR Surveill Summ"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601043340104"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050023"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2007.00245.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/314820"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/514247"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh881"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(02)02712-4"},{"issue":"6","key":"e_1_2_6_25_1","first-page":"753","article-title":"Cryptosporidiosis. 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