{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:59:37Z","timestamp":1763017177465},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T00:00:00Z","timestamp":1329696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the reactivation of varicella zoster virus (<jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>) is a common complication after allogeneic hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> meningoencephalitis is a rare life\u2010threatening infectious disease after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. We describe here a patient who developed <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> meningoencephalitis 2\u00a0years after human leukocyte antigen\u2010matched unrelated <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> for acute myeloblastic leukemia. She developed chronic graft\u2010versus\u2010host disease, and cyclosporine (<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>) was continued until 17\u00a0months after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. Low\u2010dose acyclovir (<jats:styled-content style=\"fixed-case\">ACV<\/jats:styled-content>) at 200\u00a0mg\/day was administered to prevent the reactivation of <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> from day \u22127 to the termination of <jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>. At 22\u00a0months, she suddenly developed fever, loss of consciousness, and seizure, with generalized skin rash. A high level of <jats:styled-content style=\"fixed-case\">VZV DNA<\/jats:styled-content> was detected in her cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>). She was diagnosed to have <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> meningoencephalitis. Intravenous <jats:styled-content style=\"fixed-case\">ACV<\/jats:styled-content> at 30\u00a0mg\/kg\/day was given for 2\u00a0months. Although loss of consciousness was quickly resolved, some neurologic symptoms persisted. She did not have any known risk factors for <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> reactivation. Therefore, we should keep in mind that any <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipient may develop <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> meningoencephalitis, and examination of <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> infection with an empiric administration of <jats:styled-content style=\"fixed-case\">ACV<\/jats:styled-content> may be recommended for <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients with central nervous system symptoms, even in the absence of skin manifestations.<\/jats:p>","DOI":"10.1111\/j.1399-3062.2012.00720.x","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T07:57:11Z","timestamp":1329724631000},"source":"Crossref","is-referenced-by-count":15,"title":["Varicella zoster virus meningoencephalitis after allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"14","author":[{"given":"J.","family":"Suzuki","sequence":"first","affiliation":[{"name":"Division of Hematology, Saitama Medical Center Jichi Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ashizawa","sequence":"additional","affiliation":[{"name":"Division of Hematology, Saitama Medical Center Jichi Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Okuda","sequence":"additional","affiliation":[{"name":"Division of Hematology, Saitama Medical Center Jichi Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wada","sequence":"additional","affiliation":[{"name":"Division of Hematology, Saitama Medical Center Jichi Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Division of Hematology, Saitama Medical Center Jichi Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Terasako","sequence":"additional","affiliation":[{"name":"Division of Hematology, Saitama Medical Center Jichi Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Hematology, Saitama Medical Center Jichi Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010I.","family":"Kimura","sequence":"additional","affiliation":[{"name":"Division of Hematology, Saitama Medical Center Jichi Medical University Saitama 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