{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:07:26Z","timestamp":1787508446274,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T00:00:00Z","timestamp":1337904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Transmission of pathogens from donor to recipient is a potential complication of organ transplantation. Herein, we describe the clinical course and outcomes of 4 transplant recipients who received tissues from a donor with multi\u2010organ infection with\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    carbapenemase (\n                    <jats:styled-content style=\"fixed-case\">KPC<\/jats:styled-content>\n                    )\u2010producing\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    . Recipient 1 underwent simultaneous liver and kidney transplantation for alpha\u20101 antitrypsin deficiency and alcohol\u2010related cirrhosis, and acute tubular necrosis, respectively. Soon after transplantation, he developed an infected hematoma and peritonitis due to\n                    <jats:styled-content style=\"fixed-case\">KPC<\/jats:styled-content>\n                    \u2010producing\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    despite receiving tigecycline prophylaxis. He was treated with a prolonged course of tigecycline, amikacin, and meropenem, in conjunction with surgical evacuation and percutaneous drainage of the infected fluid collections. Recipient 2 underwent living\u2010donor liver transplantation for cholangiocarcinoma and primary sclerosing cholangitis using vein graft from the donor infected with\n                    <jats:styled-content style=\"fixed-case\">KPC<\/jats:styled-content>\n                    \u2010producing\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    . Culture of the preservation fluid containing the vein graft was positive for\n                    <jats:styled-content style=\"fixed-case\">KPC<\/jats:styled-content>\n                    \u2010producing\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    . The patient received preemptive amikacin and tigecycline, and he did not develop any infection (as evidenced by negative surveillance blood cultures). The isolates from the donor and Recipients 1 and 2 were indistinguishable by pulsed\u2010field gel electrophoresis. Recipients 3 and 4 underwent kidney and heart transplantation, respectively; both patients received perioperative tigecycline prophylaxis and did not develop infections due to\n                    <jats:styled-content style=\"fixed-case\">KPC<\/jats:styled-content>\n                    \u2010producing\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    . All transplant recipients had good short\u2010term outcomes. These cases highlight the importance of inter\u2010institutional communication and collaboration to ensure the successful management of recipients of organs from donors infected with multidrug\u2010resistant organisms.\n                  <\/jats:p>","DOI":"10.1111\/j.1399-3062.2012.00742.x","type":"journal-article","created":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T06:13:49Z","timestamp":1337926429000},"page":"229-236","source":"Crossref","is-referenced-by-count":77,"title":["Outcomes of transplantation using organs from a donor infected with\n                    <i>Klebsiella pneumoniae<\/i>\n                    carbapenemase (\n                    <scp>KPC<\/scp>\n                    )\u2010producing\n                    <i>K. pneumoniae<\/i>"],"prefix":"10.1111","volume":"14","author":[{"given":"E.J.","family":"Ariza\u2010Heredia","sequence":"first","affiliation":[{"name":"William J von Liebig Transplant Center, College of Medicine Mayo Clinic Rochester Minnesota USA"},{"name":"Division of Infectious Diseases, Department of Medicine, College of Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, College of Medicine Mayo Clinic Rochester Minnesota USA"},{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, College of Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.A.","family":"Blumberg","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Raymond and Ruth Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.C.","family":"Walker","sequence":"additional","affiliation":[{"name":"William J von Liebig Transplant Center, College of Medicine Mayo Clinic Rochester Minnesota USA"},{"name":"Division of Infectious Diseases, Department of Medicine, College of Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lewis","sequence":"additional","affiliation":[{"name":"North Austin Medical Center Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Evans","sequence":"additional","affiliation":[{"name":"North Austin Medical Center Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sankar","sequence":"additional","affiliation":[{"name":"North Austin Medical Center Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Willliams","sequence":"additional","affiliation":[{"name":"Duke Transplant Services Duke University Medical Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Duke Transplant Services Duke University Medical Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Milano","sequence":"additional","affiliation":[{"name":"Duke Transplant Services Duke University Medical Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.R.","family":"Razonable","sequence":"additional","affiliation":[{"name":"William J von Liebig Transplant Center, College of Medicine Mayo Clinic Rochester Minnesota USA"},{"name":"Division of Infectious Diseases, Department of Medicine, College of Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03493.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/520442"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198403000-00020"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/11315510-000000000-00000"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/90.10.641"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.11.911"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199910270-00008"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq108"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2009.00374.x"},{"key":"e_1_2_5_11_1","volume-title":"Clinical Validation of a LightCyclerTM Assay for the Rapid Detection of KPC Producing Enterobacteriaceae from Cultured Isolates","author":"Cunnigham SA","year":"2008"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90960-5"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(96)00214-X"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053240"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8305.2006.00095.x"},{"issue":"36","key":"e_1_2_5_16_1","first-page":"1165","article-title":"Balamuthia mandrillaris transmitted through organ transplantation \u2013 Mississippi, 2009","volume":"59","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2010.00595.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03597.x"},{"issue":"50","key":"e_1_2_5_19_1","first-page":"1642","article-title":"Transmission of multidrug\u2010resistant Escherichia coli through kidney transplantation \u2013 California and Texas, 2009","volume":"59","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000239188.27153.23"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/595688"},{"issue":"1","key":"e_1_2_5_22_1","first-page":"47","article-title":"Colistin in combination with rifampin and imipenem for treating a blaVIM\u20101 metallo\u2010beta\u2010lactamase\u2010producing Enterobacter cloacae disseminated infection in a liver transplant patient","volume":"74","author":"Tascini C","year":"2008","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02038-07"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/526775"},{"issue":"5","key":"e_1_2_5_25_1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4103\/0256-4947.67087","article-title":"Evolution of tigecycline resistance in Klebsiella pneumoniae in a single patient","volume":"30","author":"Al Qadheeb NS","year":"2010","journal-title":"Ann Saudi Med"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.06.007"},{"issue":"10","key":"e_1_2_5_27_1","first-page":"256","article-title":"Guidance for control of infections with carbapenem\u2010resistant or carbapenemase\u2010producing Enterobacteriaceae in acute care facilities","volume":"58","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3062.2012.00742.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3062.2012.00742.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T08:10:30Z","timestamp":1700554230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3062.2012.00742.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,25]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1399-3062.2012.00742.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3062.2012.00742.x","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,25]]}}}