{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:17:03Z","timestamp":1790626623668,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T00:00:00Z","timestamp":1337472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The first cases of West Nile virus (<jats:styled-content style=\"fixed-case\">WNV<\/jats:styled-content>) transmitted through solid organ transplantation (<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>) were identified in 2002. Subsequently, 5 additional clusters have been reported to public health officials in the United States. Based upon a limited number of known cases, patients who acquire <jats:styled-content style=\"fixed-case\">WNV<\/jats:styled-content> from infected donor organs might be at higher risk for severe neurologic disease and death, compared with patients infected through mosquito bites. In response, some organ procurement organizations (<jats:styled-content style=\"fixed-case\">OPO<\/jats:styled-content>s) have instituted pre\u2010transplant screening of organ donors for <jats:styled-content style=\"fixed-case\">WNV<\/jats:styled-content> infection. We evaluated the current practices, concerns, and challenges related to screening organ donors for <jats:styled-content style=\"fixed-case\">WNV<\/jats:styled-content> in the United States by reviewing the relevant medical literature and interviewing key stakeholders. Screening organ donors for <jats:styled-content style=\"fixed-case\">WNV<\/jats:styled-content> is not required by national policy. In 2008, 11 (19%) of 58 <jats:styled-content style=\"fixed-case\">OPO<\/jats:styled-content>s performed <jats:styled-content style=\"fixed-case\">WNV<\/jats:styled-content> screening using nucleic acid amplification testing (<jats:styled-content style=\"fixed-case\">NAT<\/jats:styled-content>). These <jats:styled-content style=\"fixed-case\">OPO<\/jats:styled-content>s differ in their screening strategies, <jats:styled-content style=\"fixed-case\">NAT<\/jats:styled-content> performed, and logistical challenges. Concerns of delays in receiving <jats:styled-content style=\"fixed-case\">NAT<\/jats:styled-content> results before transplant and potential false\u2010positive results leading to organ wasting are limitations to more widespread screening. Furthermore, it is unknown if <jats:styled-content style=\"fixed-case\">WNV<\/jats:styled-content> screening practices decrease <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>\u2010related morbidity and mortality, or if screening is cost\u2010effective. Additional data are needed to assess and improve transplant outcomes related to <jats:styled-content style=\"fixed-case\">WNV<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/j.1399-3062.2012.00743.x","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T04:07:00Z","timestamp":1337573220000},"page":"268-277","source":"Crossref","is-referenced-by-count":70,"title":["Current practices and evaluation of screening solid organ donors for West Nile virus"],"prefix":"10.1111","volume":"14","author":[{"given":"R.J.","family":"Nett","sequence":"first","affiliation":[{"name":"Arboviral Diseases Branch Centers for Disease Control and Prevention (CDC) Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Kuehnert","sequence":"additional","affiliation":[{"name":"Office of Blood, Organ, and Other Tissue Safety CDC Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.G.","family":"Ison","sequence":"additional","affiliation":[{"name":"Divisions of Infectious Diseases and Organ Transplantation Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"Orlowski","sequence":"additional","affiliation":[{"name":"Center for Donation and Transplant Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Arboviral Diseases Branch Centers for Disease Control and Prevention (CDC) Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Staples","sequence":"additional","affiliation":[{"name":"Arboviral Diseases Branch Centers for Disease Control and Prevention (CDC) Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00368-7"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Centers for Disease Control and Prevention. 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