{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:29:21Z","timestamp":1770823761859,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T00:00:00Z","timestamp":1343952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>After allogeneic hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>), viral infections\/reactivations are a frequent complication, sometimes with fatal outcome. Thus, early diagnosis is recommended by screening of whole blood or plasma preparations using highly sensitive molecular techniques that test for the most common viral pathogens, such as <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>pstein\u2013<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arr virus, cytomegalovirus, and adenoviruses (<jats:styled-content style=\"fixed-case\">ADV<\/jats:styled-content>s). Despite this approach, not every reactivation\/infection can be adequately detected or excluded, even with highly sensitive polymerase chain reaction. Particularly after toxic treatment, uncommon infections or infections resistant to first\u2010line treatment can occur, even in unusual locations. Herein, we present the case of a child with Philadelphia chromosome\u2010positive acute lymphoblastic leukemia after allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> who suffered from 5 different viral reactivations\/infections, including acyclovir\u2010resistant herpes simplex virus type 1 esophagitis, human herpesvirus 6 encephalitis, rotavirus gastroenteritis, respiratory syncytial virus pneumonia, and <jats:styled-content style=\"fixed-case\">ADV<\/jats:styled-content> esophagitis, despite routinely performed blood examinations for viral pathogens remaining unrevealing at all times.<\/jats:p>","DOI":"10.1111\/j.1399-3062.2012.00778.x","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T18:39:06Z","timestamp":1344019146000},"source":"Crossref","is-referenced-by-count":9,"title":["Multiple viral infections after haploidentical hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia"],"prefix":"10.1111","volume":"14","author":[{"given":"J.","family":"Ernst","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Kinder\u2010 und Jugendmedizin Universit\u00e4tsklinikum Jena, Friedrich\u2010Schiller\u2010Universit\u00e4t Jena Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sauerbrei","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie und Antivirale Therapie Universit\u00e4tsklinikum Jena, Friedrich\u2010Schiller\u2010Universit\u00e4t Jena Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Krumbholz","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie und Antivirale Therapie Universit\u00e4tsklinikum Jena, Friedrich\u2010Schiller\u2010Universit\u00e4t Jena Jena Germany"},{"name":"Institut f\u00fcr Medizinische Mikrobiologie Universit\u00e4tsklinikum Jena, Friedrich\u2010Schiller\u2010Universit\u00e4t Jena Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Egerer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Mikrobiologie Universit\u00e4tsklinikum Jena, Friedrich\u2010Schiller\u2010Universit\u00e4t Jena Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010J.","family":"Mentzel","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Diagnostische und Interventionelle Radiologie Universit\u00e4tsklinikum Jena, Friedrich\u2010Schiller\u2010Universit\u00e4t Jena Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kurzai","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinder\u2010 und Jugendmedizin Universit\u00e4tsklinikum Jena, Friedrich\u2010Schiller\u2010Universit\u00e4t Jena Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"H\u00e4fer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinder\u2010 und Jugendmedizin Universit\u00e4tsklinikum Jena, Friedrich\u2010Schiller\u2010Universit\u00e4t Jena Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.F.","family":"Beck","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinder\u2010 und Jugendmedizin Universit\u00e4tsklinikum Jena, Friedrich\u2010Schiller\u2010Universit\u00e4t Jena Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Gruhn","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinder\u2010 und Jugendmedizin Universit\u00e4tsklinikum Jena, Friedrich\u2010Schiller\u2010Universit\u00e4t Jena Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66998-X"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-207001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318203e279"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200203000-00013"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200004000-00009"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2009.01226.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(00)00069-X"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2010.03.002"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1870"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.1.114-128.2003"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(02)00263-9"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2007.00822.x"},{"issue":"12","key":"e_1_2_5_14_1","first-page":"1407","article-title":"Herpes simplex esophagitis from 1307 autopsy cases","volume":"18","author":"Itoh T","year":"2003","journal-title":"J Gastroenterol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.7.3105-3110.2001"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0966-842X(94)90652-1"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/428060"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(06)70012-9"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318224947f"},{"issue":"12","key":"e_1_2_5_20_1","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1182\/blood.V87.12.5341.bloodjournal87125341","article-title":"Human herpesvirus 6: infection and disease following autologous and allogeneic bone marrow transplantation","volume":"87","author":"Kadakia MP","year":"1996","journal-title":"Blood"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.05.009"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/338044"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702118"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21184"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-263400"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3180437ded"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701563"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.5.3.262"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/429235"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200204270-00010"},{"issue":"6","key":"e_1_2_5_31_1","first-page":"573","article-title":"Virus recovery from stools of patients undergoing bone marrow transplantation","volume":"12","author":"Troussard X","year":"1993","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_32_1","first-page":"CD003742","article-title":"Oral immunoglobulin for the treatment of rotavirus diarrhea in low birth weight infants","volume":"10","author":"Pammi M","year":"2011","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3062.2012.00778.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3062.2012.00778.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T13:22:29Z","timestamp":1700572949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3062.2012.00778.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,3]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1399-3062.2012.00778.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3062.2012.00778.x","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,3]]}}}