{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:18:12Z","timestamp":1789417092127,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T00:00:00Z","timestamp":1347408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Backgrounds and aims<\/jats:title><jats:p>Organ shortage is a major problem in transplantation. The use of organs from hepatitis B surface antigen (<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg)\u2010negative and hepatitis B core antibody (<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>cAb)\u2010positive donors could significantly increase the donor pool. However, little information is available about the impact of <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>cAb status of renal donors on viral transmission to recipients. To address this issue, the present quantitative review of relevant studies has been performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Electronic databases including Medline, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ISI<\/jats:styled-content>, and Scopus were systematically searched for studies that evaluated risk of hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>) transmission through renal transplantation from <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg\u2010\/<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>cAb+ donors. Eligible studies were identified according to predefined criteria. The final outcome was one of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> markers seroconversion defined as <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg, hepatitis B surface antibody (<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAb), or <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>cAb detection in previously seronegative end\u2010stage renal disease (<jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content>) patients after transplantation, and without other identified major sources of infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies with 1385 eligible kidney recipients were included. In total, 45 subjects showed seroconversion of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> markers as follows: <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) (0.28%; 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.006; 0.57), <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>cAb (<jats:italic>n<\/jats:italic>\u00a0=\u00a032), <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAb (<jats:italic>n<\/jats:italic>\u00a0=\u00a05), and either <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>cAb or <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAb (<jats:italic>n<\/jats:italic>\u00a0=\u00a04). The total rate of seroconversion after renal transplantation was calculated to be 3.24% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.31\u20134.18).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our review indicates that the risk of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> transmission from <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>cAb\u2010positive kidney donors is extremely low. Therefore, kidneys from these donors can be transplanted safely into <jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-3062.2012.00782.x","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T04:07:07Z","timestamp":1347509227000},"page":"445-451","source":"Crossref","is-referenced-by-count":55,"title":["Renal grafts from anti\u2010hepatitis B core\u2010positive donors: a quantitative review of the literature"],"prefix":"10.1111","volume":"14","author":[{"given":"N.","family":"Mahboobi","sequence":"first","affiliation":[{"name":"Tehran Hepatitis Center Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.V.","family":"Tabatabaei","sequence":"additional","affiliation":[{"name":"Gastroenterologishe Klinik Westf\u00e4lische Wilhelms\u2010Universit\u00e4t M\u00fcnster St.\u2010Marien\u2010Hospital GmbH L\u00fcnen 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