{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:05:56Z","timestamp":1768889156083,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T00:00:00Z","timestamp":1143676800000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Xenotransplantation"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p><jats:bold>Abstract: Background: <\/jats:bold> The longer waiting time for a liver graft in patients with blood group O makes it necessary to expand the donor pool for these patients. This applies in both urgent situations and for elective patients. We report on our experience with ABO\u2010incompatible liver transplantation using A<jats:sub>2<\/jats:sub> and B non\u2010secretor donors here.<\/jats:p><jats:p><jats:bold>Patients and methods: <\/jats:bold> Between 1996 and 2005, 12 adult blood group O recipients (seven male\/five female) received ABO\u2010incompatible cadaveric liver grafts (10 A<jats:sub>2<\/jats:sub> donors, two B non\u2010secretor donors). The indications were either rapid deterioration of liver function or hepatocellular cancer, in blood group O recipients, where an ABO\u2010identical\/compatible graft was not available. Mean recipient age was 54\u00b18 (mean\u00b1SD)\u2003yr. All pre\u2010operative CDC crossmatches were negative. The initial immunosuppression was induction therapy with antithymocyte globulin (<jats:italic>n<\/jats:italic>=3), interleukin 2 receptor antagonists (<jats:italic>n<\/jats:italic>=3) or anti\u2010CD20 antibody (rituximab) (<jats:italic>n<\/jats:italic>=1), followed by a tacrolimus\u2010based protocol. Three patients underwent plasmapheresis post\u2010transplantation. Baseline biopsies were taken before or immediately after reperfusion of the graft and after grafting when clinically indicated. No pre\u2010operative plasmapheresis, immunoadsorption or splenectomies were performed.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Patient and graft survival was 10\/12 (83%) and 8\/12 (67%), respectively, with a 6.5\u2010month median follow\u2010up (range 10 days to 109 months). Two patients (B non\u2010secretor grafts) died of multiorgan failure probably because of a poor condition before transplantation. Three patients were retransplanted. Causes of graft loss were bacterial arteritis (<jats:italic>n<\/jats:italic>=1), death with a functioning graft (<jats:italic>n<\/jats:italic>=1) and portal vein thrombosis (<jats:italic>n<\/jats:italic>=2). In one of the patients with portal vein thrombosis, an anti\u2010A titer increase occurred concomitantly, and ABO incompatibility as the cause of the thrombosis cannot be excluded. Seven acute rejections occurred in five patients and all were reversed by steroids or increased tacrolimus dosage. The pre\u2010transplant anti\u2010A titers tested against A<jats:sub>1<\/jats:sub> red blood cells were 1 to 128 (NaCl technique) and 4 to 1024 (indirect antiglobulin technique, IAT); the maximum postoperative titers were 16 to 2048 (NaCl) and 256 to 32 000 (IAT).<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> The favorable outcome of A<jats:sub>2<\/jats:sub> to O grafting, with a patient survival of 10\/10 and a graft survival of 8\/10, makes it possible to also consider this blood group combination in non\u2010urgent situations. The use of non\u2010secretor donor grafts is interesting but has to be further documented. There was no hyperacute rejection or increased rate of rejection. Anti\u2010A\/B titer changes seem not to play a significant role in the monitoring of ABO\u2010incompatible liver transplantation.<\/jats:p>","DOI":"10.1111\/j.1399-3089.2006.00286.x","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T10:33:00Z","timestamp":1143714780000},"page":"154-159","source":"Crossref","is-referenced-by-count":31,"title":["Adult ABO\u2010incompatible liver transplantation, using A<sub>2<\/sub> and B donors"],"prefix":"10.1111","volume":"13","author":[{"given":"Ulrika","family":"Skogsberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Breimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Styrbj\u00f6rn","family":"Friman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Mj\u00f6rnstedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"M\u00f6lne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Olausson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Rydberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian T.","family":"Svalander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"B\u00e4ckman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,30]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"1124","article-title":"The use of ABO\u2010incompatible grafts in liver transplantation","volume":"59","author":"Farges O","year":"1995","journal-title":"a life saving procedure in highly selected patients"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199409150-00003"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92082-S"},{"key":"e_1_2_7_5_2","first-page":"342","article-title":"Liver transplantation across ABO blood groups","volume":"100","author":"Robert D","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_7_6_2","first-page":"59","article-title":"ABO\u2010incompatible orthotopic liver allografting in urgent indications","volume":"174","author":"Reding R","year":"1992","journal-title":"Surg Gynocol Obstretics"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2001.00313.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199904150-00024"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3089.2006.00287.x"},{"key":"e_1_2_7_10_2","volume-title":"The Distribution of the Human Blood Groups and Other Polymorphisms","author":"Mourant AE","year":"1976"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/162933a0"},{"key":"e_1_2_7_12_2","unstructured":"United Network for Organ Sharing http:\/\/www.unos.org."},{"key":"e_1_2_7_13_2","first-page":"658","article-title":"Banff schema for grading liver allograft rejection","volume":"25","author":"Anthony J","year":"1997","journal-title":"an international consensus document"},{"key":"e_1_2_7_14_2","first-page":"88","article-title":"The specific distribution of glycolipid\u2010based blood group A antigens in human kidney related to A1\/A2, Lewis and secretor status of single individuals. A possible molecular explanation for the successful transplantation of A2 kidneys into O recipients","volume":"42","author":"Breimer ME","year":"1986","journal-title":"Transplantation"},{"key":"e_1_2_7_15_2","unstructured":"The European Transplant Liver Registry http:\/\/www.ELTR.org."}],"container-title":["Xenotransplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-3089.2006.00286.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-3089.2006.00286.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T17:34:26Z","timestamp":1696872866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-3089.2006.00286.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1111\/j.1399-3089.2006.00286.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-3089.2006.00286.x","archive":["Portico"],"relation":{},"ISSN":["0908-665X","1399-3089"],"issn-type":[{"value":"0908-665X","type":"print"},{"value":"1399-3089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}