{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T10:43:10Z","timestamp":1744627390956},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,3,8]],"date-time":"2004-03-08T00:00:00Z","timestamp":1078704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p><jats:bold>Objectives:\u2002<\/jats:bold> To evaluate co\u2010segregation and genetic associations between von Willebrand's disease (vWD) and psychotic disorders.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The study was initiated following ascertainment of a nuclear family in which four members were diagnosed with vWD and psychotic\/mood disorders. As co\u2010segregation was uncertain in the extended pedigree, we also investigated population\u2010based linkage and association using polymorphisms of <jats:italic>vWF<\/jats:italic>, the gene conferring susceptibility to vWD. Three common <jats:italic>vWF<\/jats:italic> polymorphisms were investigated among 194 patients with psychotic disorders (bipolar I disorder, BD I; schizoaffective disorder, SZA and schizophrenia, SZ) and their parents. The cases were also compared with unrelated population\u2010based controls (n\u2003=\u2003183).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The transmission disequilibrium test and related analyses suggested nominally significant transmission distortion of one allele and related haplotypes to the probands from their parents. The most significant results were obtained among patients with BD I, and similar trends were also evident in the SZ sample. Comparisons between the cases and population\u2010based controls did not reveal associations, though marginally significant case\u2013control differences were obtained in the BD I sample.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These studies are consistent with association and linkage between vWF and BD I. However, given the relatively small sample, stochastic variation is an alternative explanation.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2004.00103.x","type":"journal-article","created":{"date-parts":[[2004,12,20]],"date-time":"2004-12-20T21:04:57Z","timestamp":1103576697000},"page":"150-155","source":"Crossref","is-referenced-by-count":4,"title":["von Willebrand's disease and psychotic disorders: co\u2010segregation and genetic associations"],"prefix":"10.1111","volume":"6","author":[{"given":"Yu\u2010Sang","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Cortese","family":"Hassett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung\u2010Yeon","family":"Lee\u2010Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Haracznak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Ranade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravinder","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Kupfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franklin","family":"Bontempo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishwajit L","family":"Nimgaonkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,8]]},"reference":[{"key":"e_1_2_16_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.2.454.454"},{"key":"e_1_2_16_3_2","first-page":"34","article-title":"Molecular genetics of von Willebrand disease","volume":"41","author":"Mazurier C","year":"1998","journal-title":"Ann Genet"},{"key":"e_1_2_16_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.67.1.395"},{"key":"e_1_2_16_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3874428"},{"key":"e_1_2_16_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)47144-5"},{"key":"e_1_2_16_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1651577"},{"key":"e_1_2_16_8_2","first-page":"657","volume-title":"The Molecular Basis of Blood Diseases","author":"Sadler JE","year":"1994"},{"key":"e_1_2_16_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00124509-200003000-00009"},{"key":"e_1_2_16_10_2","first-page":"983","article-title":"The TDT and other family\u2010based tests for linkage disequilibrium and association","volume":"59","author":"Spielman RS","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_16_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950110009002"},{"key":"e_1_2_16_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.7.1729"},{"key":"e_1_2_16_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.16.4961-a"},{"key":"e_1_2_16_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.24.7467-a"},{"key":"e_1_2_16_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/301904"},{"key":"e_1_2_16_16_2","first-page":"1347","article-title":"Parametric and nonparametric linkage analysis: a unified multipoint approach","volume":"58","author":"Kruglyak L","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_16_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/302566"},{"key":"e_1_2_16_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/302577"},{"key":"e_1_2_16_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000022901"},{"key":"e_1_2_16_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/303069"},{"key":"e_1_2_16_21_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.148401"},{"issue":"23","key":"e_1_2_16_22_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1192\/S0007125000292684","article-title":"Prenatal factors in the pathogenesis of schizophrenia","volume":"164","author":"Huttunen MO","year":"1994","journal-title":"Br J Psychiatry"},{"key":"e_1_2_16_23_2","first-page":"134","volume-title":"Fetal Neural Development and Adult Schizophrenia","author":"Lyon M","year":"1991"},{"key":"e_1_2_16_24_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.160.1.112"},{"key":"e_1_2_16_25_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.160.5.715a"},{"key":"e_1_2_16_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009923"},{"key":"e_1_2_16_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320570319"},{"key":"e_1_2_16_28_2","doi-asserted-by":"publisher","DOI":"10.1086\/302929"},{"key":"e_1_2_16_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00218841"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-5618.2004.00103.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-5618.2004.00103.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T18:34:58Z","timestamp":1697394898000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-5618.2004.00103.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,8]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1111\/j.1399-5618.2004.00103.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-5618.2004.00103.x","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,8]]}}}