{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:05:17Z","timestamp":1759032317494},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,14]],"date-time":"2005-01-14T00:00:00Z","timestamp":1105660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Typical experimental categorizations of treatment responses in bipolar disorder (BPD) patients may have limited relationship to clinical recovery or functional status, and there is inadequate research on such clinically important outcomes.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We analyzed data from a study of open continuation of olanzapine treatment following a 3\u2010week placebo\u2010controlled trial involving initially hospitalized adult subjects with DSM\u2010IV BP\u2010I mania to estimate rates and times to <jats:italic>symptomatic remission<\/jats:italic> (low scores on standardized symptomatic assessments) and <jats:italic>clinical recovery<\/jats:italic> (remission sustained \u22658\u2003weeks), associated clinical factors, and functional outcomes.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> During treatment with olanzapine for 27.9\u2003\u00b1\u200320.1\u2003weeks, <jats:italic>symptomatic remission<\/jats:italic> was attained by 70% of subjects, half by 8\u2003weeks (95% CI 6\u201310) weeks, and later lost by 82% of remitted subjects; remitted (versus non\u2010remitted) subjects had slightly lower baseline clinical global impression scores and greater trial\u2010completion. <jats:italic>Sustained clinical recovery<\/jats:italic> was attained by only 40 of 113 (35%) of subjects, half by 36 (95% CI 20\u201340) weeks, and later lost by 45%. Subjects with above\u2010median (&gt;12) initial Hamilton\u2010Depression rating scale depression scores were half as likely to recover (p\u2003=\u20030.016) and did so much later (36 versus 12\u2003weeks) than those with lower scores. At final assessment, self\u2010rated well being (SF\u201036 psychosocial functioning scores) improved substantially more among recovered versus non\u2010recovered subjects (mean changes: 87% versus 23%), and two\u2010thirds of recovered subjects remained unemployed\u2010for\u2010pay while half received disability\u2010compensation.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Clinically meaningful symptomatic remission and recovery in relatively severely ill adult bipolar I manic patients were achieved slowly and sustained by only some patients within an average of 7\u2003months of continuous treatment. These clinically relevant outcomes were worse with relatively high initial dysphoria ratings. Well\u2010being was rated higher by recovered subjects, but their ability to work and live independently were markedly impaired. These findings underscore the emerging view that BPD can often be severe, slow to remit, and disabling, particularly in association with prominent depression\u2010dysphoria symptoms. Improved treatments for BPD are needed, guided by longitudinal assessments of clinically meaningful measures of symptomatic recovery and functional outcome.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2004.00171.x","type":"journal-article","created":{"date-parts":[[2005,1,14]],"date-time":"2005-01-14T10:34:10Z","timestamp":1105698850000},"page":"68-76","source":"Crossref","is-referenced-by-count":33,"title":["Recovery and functional outcomes following olanzapine treatment for bipolar I mania"],"prefix":"10.1111","volume":"7","author":[{"given":"KN","family":"Roy Chengappa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Hennen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross J","family":"Baldessarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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