{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:44:31Z","timestamp":1792622671161,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T00:00:00Z","timestamp":1134000000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Despite evidence indicating high morbidity associated with pediatric bipolar disorder (BP), little is known about the prevalence and clinical correlates of suicidal behavior among this population.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To investigate the prevalence of suicidal behavior among children and adolescents with BP, and to compare subjects with a history of suicide attempt to those without on demographic, clinical, and familial risk factors.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Subjects were 405 children and adolescents aged 7\u201317\u2003years, who fulfilled DSM\u2010IV criteria for BPI (n\u2003=\u2003236) or BPII (n\u2003=\u200329), or operationalized criteria for BP not otherwise specified (BP NOS; n\u2003=\u2003140) via the Schedule for Affective Disorders and Schizophrenia for School\u2010Aged Children. As part of a multi\u2010site longitudinal study of pediatric BP (Course and Outcome of Bipolar Youth), demographic, clinical, and family history variables were measured at intake via clinical interview with the subject and a parent\/guardian.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Nearly one\u2010third of BP patients had a lifetime history of suicide attempt. Attempters, compared with non\u2010attempters, were older, and more likely to have a lifetime history of mixed episodes, psychotic features, and BPI. Attempters were more likely to have a lifetime history of comorbid substance use disorder, panic disorder, non\u2010suicidal self\u2010injurious behavior, family history of suicide attempt, history of hospitalization, and history of physical and\/or sexual abuse. Multivariate analysis found that the following were the most robust set of predictors for suicide attempt: mixed episodes, psychosis, hospitalization, self\u2010injurious behavior, panic disorder, and substance use disorder.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These findings indicate that children and adolescents with BP exhibit high rates of suicidal behavior, with more severe features of BP illness and comorbidity increasing the risk for suicide attempt. Multiple clinical factors emerged distinguishing suicide attempters from non\u2010attempters. These clinical factors should be considered in both assessment and treatment of pediatric BP.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2005.00263.x","type":"journal-article","created":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T14:18:31Z","timestamp":1134051511000},"page":"525-535","source":"Crossref","is-referenced-by-count":171,"title":["History of suicide attempts in pediatric bipolar disorder: factors associated with increased risk"],"prefix":"10.1111","volume":"7","author":[{"given":"Tina R","family":"Goldstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Birmaher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Axelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal D","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Strober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Kay","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Valeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Chiappetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrietta","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A","family":"Bridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Brent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.11.1517"},{"key":"e_1_2_6_3_2","volume-title":"Manic\u2010Depressive Illness","author":"Goodwin FK","year":"1990"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(94)90104-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.01.022"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0503"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800300079011"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199305000-00006"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1998.tb10116.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1979.01780060088010"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199506000-00012"},{"key":"e_1_2_6_12_2","first-page":"7","volume-title":"Bipolar Disorder in Childhood and Early Adolescence","author":"Lewinsohn PM","year":"2003"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/104454603322724896"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01064927"},{"key":"e_1_2_6_15_2","first-page":"123","volume-title":"Familial factors in suicidal behavior","author":"Linkowski P","year":"1988"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440X(80)90019-X"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01239-2"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00129-9"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.6.882"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.150.6.928"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.9.1312"},{"key":"e_1_2_6_22_2","first-page":"31","article-title":"Identifying and managing suicide risk in bipolar patients","volume":"62","author":"Oquendo MA","year":"2001","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1521\/suli.34.2.172.32783"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02195974"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.145.7.849"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(05)70101-5"},{"key":"e_1_2_6_27_2","first-page":"95","article-title":"Suicide attempts in primary major depression subtypes","volume":"19","author":"Perugi G","year":"1988","journal-title":"Psychiatr Fenn"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0802"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb05796.x"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/10673220490425924"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00175-X"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199507000-00010"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199707000-00021"},{"key":"e_1_2_6_34_2","first-page":"463","volume-title":"J Child Adolesc Psychopharmacol","author":"Axelson D","year":"2003"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200108000-00007"},{"key":"e_1_2_6_36_2","article-title":"Clinical course of children and adolescents with bipolar spectrum disorders","author":"Birmaher B","journal-title":"Archives of General Psychiatry"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1943-278X.1996.tb00609.x"},{"key":"e_1_2_6_38_2","volume-title":"Assessment of Suicidal Behaviors and Risk among Children and Adolescents","author":"Goldston D","year":"2000"},{"key":"e_1_2_6_39_2","volume-title":"Four\u2010factor Index of Social Status","author":"Hollingshead A","year":"1975"},{"key":"e_1_2_6_40_2","volume-title":"The Structured Clinical Interview for DSM\u2010III\u2010R\/DSM\u2010IV","author":"Spitzer RL","year":"1996"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.7.675"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790100074010"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200104000-00011"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1989.tb10259.x"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.3.427"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.114.1.140"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1027\/\/0227-5910.20.1.8"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-440X(96)90044-9"},{"key":"e_1_2_6_49_2","volume-title":"Cognitive\u2010behavioral Treatment of Borderline Personality Disorder","author":"Linehan MM","year":"1993"},{"key":"e_1_2_6_50_2","first-page":"41","article-title":"Borderline: an adjective in search of a noun","volume":"46","author":"Akiskal HS","year":"1985","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830120085015"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012657951-2\/50002-9"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-5618.2005.00263.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-5618.2005.00263.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:04:09Z","timestamp":1696874649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-5618.2005.00263.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1111\/j.1399-5618.2005.00263.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-5618.2005.00263.x","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}