{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:57:33Z","timestamp":1779361053623,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T00:00:00Z","timestamp":1137024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:\u2002<\/jats:bold>\n                    To compare the clinical presentation of patients with early\u2010onset (age &lt;18\u2003years) and typical\u2010onset (age 20\u201330\u2003years) bipolar disorder at the time of first hospitalization.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    Patients, aged 12\u201345\u2003years at their first psychiatric hospitalization, with a DSM\u2010IV diagnosis of bipolar disorder, manic or mixed, were evaluated on measures of manic, depressive, and positive psychotic symptoms. Differences in symptom profiles between early\u2010 and typical\u2010onset groups were examined.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    One hundred three early\u2010onset and 58 typical\u2010onset patients were compared. Mixed episodes were more common in the early\u2010onset group, while psychotic features and current substance use were more common in the typical\u2010onset group. There was no significant difference in manic symptom severity ratings between early\u2010 and typical\u2010onset groups (\n                    <jats:italic>F<\/jats:italic>\n                    \u2003=\u20031.8, df\u2003=\u200311, 144, p\u2003=\u20030.06). However, these groups differed in depressive (\n                    <jats:italic>F<\/jats:italic>\n                    \u2003=\u20034.2, df\u2003=\u200316, 139, p\u2003&lt;\u20030.001) and positive psychotic (\n                    <jats:italic>F<\/jats:italic>\n                    \u2003=\u20032.8, df\u2003=\u200316, 139, p\u2003=\u20030.001) symptom profiles. Typical\u2010onset bipolar patients reported more severe weight loss and formal thought disorder compared with early\u2010onset patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    Depressive and positive psychotic symptoms may differ in association with age at onset among patients with bipolar disorder. Additional studies are necessary to determine whether homogeneous phenotypes of bipolar disorder can be delineated based upon age at onset.\n                  <\/jats:p>","DOI":"10.1111\/j.1399-5618.2006.00247.x","type":"journal-article","created":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T08:25:50Z","timestamp":1137054350000},"page":"91-94","source":"Crossref","is-referenced-by-count":23,"title":["Phenomenology associated with age at onset in patients with bipolar disorder at their first psychiatric hospitalization"],"prefix":"10.1111","volume":"8","author":[{"given":"Nick C","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa P","family":"DelBello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Paul E","family":"Keck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M","family":"Strakowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00306-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.2.213"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.1.44"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2003.10.002"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00111-1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.5.999"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(00)00015-7"},{"key":"e_1_2_6_9_2","volume-title":"Structured Clinical Interview for DSM\u2010IV Axis I Disorders\u2010Patient Edition (SCID\u2010I\/P, Version 2.0)","author":"First MB","year":"1995"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200104000-00014"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2001.030201.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_6_14_2","volume-title":"The Scale for the Assessment of Positive Symptoms (SAPS)","author":"Andreasen NC","year":"1984"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/10445460050167269"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199507000-00010"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00310-D"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800130015003"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(03)00053-3"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2005.00181.x"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-5618.2006.00247.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-5618.2006.00247.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T07:22:01Z","timestamp":1764228121000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-5618.2006.00247.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,12]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1111\/j.1399-5618.2006.00247.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-5618.2006.00247.x","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,12]]}}}