{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:59:15Z","timestamp":1781704755684,"version":"3.54.5"},"reference-count":183,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T00:00:00Z","timestamp":1147392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Objectives:\u2002<\/jats:bold> Bipolar disorders are reported to have a high incidence during childbearing years and the need may arise to start or continue a pharmacological treatment during pregnancy and the postpartum period. In the last few years several investigations have evaluated the efficacy of emerging mood\u2010stabilizing agents in the treatment of bipolar disorders, such as lamotrigine, olanzapine, risperidone, quetiapine, aripiprazole and ziprasidone. A number of studies, which examined the use of oxcarbazepine, point to its potential usefulness in prophylactic treatment. The aim of this review is to compare information from the literature on the safety of lamotrigine, oxcarbazepine, risperidone, olanzapine, and quetiapine to the safety data on classic mood stabilizers during pregnancy and the postpartum period.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A computerized search carried out from 1980 to April 5, 2006 led to the summarization of the results. (References were updated after acceptance and prior to publication.)<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Emerging mood stabilizers show uncertain safety parameters in pregnancy and lactation. Limited information on lamotrigine and oxcarbazepine does not suggest a clear increase in teratogenicity, while olanzapine appears to be associated with a higher risk of metabolic complications in pregnant women. Data about risperidone and quetiapine are still inconclusive. Finally, the literature on the safety of these compounds in breastfeeding is anecdotal.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Untreated pregnant bipolar women are at an increased risk of poor obstetrical outcomes and relapse of affective symptoms. On the other hand, classic antiepileptic drugs are well\u2010known human teratogens, whereas data on lithium are partially ambiguous. The safety of emerging mood stabilizers in pregnancy and breastfeeding has not been examined extensively. Therefore, when approaching bipolar disorder, if possible, each episode must be considered separately.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2006.00295.x","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T16:04:42Z","timestamp":1147449882000},"page":"207-220","source":"Crossref","is-referenced-by-count":52,"title":["Prophylactic treatment of bipolar disorder in pregnancy and breastfeeding: focus on emerging mood stabilizers"],"prefix":"10.1111","volume":"8","author":[{"given":"Salvatore","family":"Gentile","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,12]]},"reference":[{"key":"e_1_2_12_2_2","first-page":"4","volume-title":"Special needs of women with Bipolar Disorder","author":"Swann AC","year":"2004"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-5618.2003.00089.x"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1450579"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.155.4.496"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.4.608"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2005.00526.x"},{"issue":"1","key":"e_1_2_12_8_2","first-page":"7","article-title":"Long\u2010term treatment in bipolar disorder","volume":"66","author":"Swann AC","year":"2005","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2005.00523.x"},{"key":"e_1_2_12_10_2","volume-title":"Efficacy Supplements Approved in Calendar Year 2005","author":"Food and Drug Administration","year":"2005"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/57.1.179"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00338-5"},{"issue":"3","key":"e_1_2_12_13_2","first-page":"15","article-title":"Psychotropic drugs and adverse events in the treatment of bipolar disorders revisited","volume":"63","author":"McIntyre RS","year":"2002","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_12_14_2","first-page":"1","article-title":"A review of evidence for carbazepine and oxcarbazepine in the treatment of bipolar disorder","volume":"30","author":"Hirschfeld RM","year":"2004","journal-title":"Int J Neuropsychopharmacol"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00407-X"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/10401239309148824"},{"key":"e_1_2_12_17_2","first-page":"504","volume-title":"Lithium Encyclopaedia for Clinical Practice","author":"Jefferson JW","year":"1987"},{"key":"e_1_2_12_18_2","first-page":"31","article-title":"Reproductive mood disorder","volume":"10","author":"Rapkin AJ","year":"2003","journal-title":"Primary Psychiatry"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.2.179"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0403"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1017\/S109285290000897X"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)90459-0"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900008993"},{"key":"e_1_2_12_24_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1001\/jama.1994.03510260078033","article-title":"A reevaluation of risk of in utero exposure to lithium","volume":"271","author":"Cohen LS","year":"1994","journal-title":"J Am Med Assoc"},{"key":"e_1_2_12_25_2","first-page":"252","volume-title":"Psychotropic Drug Directory 2003\/2004. The Professionals\u2019 Pocket Handbook & Aide Memoire","author":"Bazire S","year":"2003"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30501"},{"issue":"6","key":"e_1_2_12_27_2","first-page":"57","article-title":"The use of lithium and management of women with bipolar disorder during pregnancy and lactation","volume":"59","author":"Llewellyn A","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C123"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674370505000317"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.11.2162"},{"key":"e_1_2_12_31_2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1542\/peds.47.1.94","article-title":"Lithium toxicity in a newborn","volume":"47","author":"Woody JN","year":"1971","journal-title":"Pediatrics"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(72)80111-2"},{"key":"e_1_2_12_33_2","first-page":"400","article-title":"Breast\u2010feeding during lithium therapy","volume":"139","author":"Skausig OB","year":"1977","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v61n0202"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(98)00084-9"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199103073241006"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198906223202505"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.75.6.517"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.074203"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-198409000-00002"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200528080-00004"},{"issue":"4","key":"e_1_2_12_42_2","first-page":"42","article-title":"The reproductive safety profile of mood stabilizers, atypical antipsychotics, and broad\u2010spectrum psychotropics","volume":"63","author":"Ernst LC","year":"2002","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000154516.43630.C5"},{"key":"e_1_2_12_44_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/00007611-200194030-00007","article-title":"Effects of antimanic mood\u2010stabilizing drugs on fetuses, neonates, and nursing infants","volume":"94","author":"Iqbal MM","year":"2001","journal-title":"South Med J"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290123"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.029132"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2005.06.001"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000228)90:5<376::AID-AJMG6>3.0.CO;2-V"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80750-1"},{"key":"e_1_2_12_50_2","first-page":"273","article-title":"Depressive symptoms among pregnant women screened in obstetrics setting","volume":"121","author":"Marcus SM","year":"2003","journal-title":"J Womens Health"},{"key":"e_1_2_12_51_2","first-page":"223","article-title":"Valproic acid use in psychiatry: issues in treating women of reproductive age","volume":"23","author":"Kennedy D","year":"1998","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.69.3_Spec_No.288"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320190308"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00476-9"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00458.x"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70292-0"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70506-0"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.45901.x"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.451105.x"},{"key":"e_1_2_12_60_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000154515.94346.89"},{"issue":"8","key":"e_1_2_12_61_2","first-page":"60","article-title":"Which antiepileptic drug is safest in pregnancy?","volume":"44","author":"Morrow J","year":"2003","journal-title":"Epilepsia"},{"key":"e_1_2_12_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-5868(03)00158-9"},{"key":"e_1_2_12_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.451103.x"},{"key":"e_1_2_12_64_2","first-page":"397","article-title":"New antiepileptic drug in pregnancy: outcome of 12 exposed pregnancies","volume":"57","author":"Cissoko H","year":"2002","journal-title":"Th\u00e9rapie"},{"key":"e_1_2_12_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb00701.x"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2003.00200.x"},{"key":"e_1_2_12_67_2","unstructured":"GlaxoSmithKline2002. Data on file."},{"key":"e_1_2_12_68_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200427030-00002"},{"key":"e_1_2_12_69_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.2.251"},{"key":"e_1_2_12_70_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000133213.10244.FD"},{"key":"e_1_2_12_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2005.06.004"},{"key":"e_1_2_12_72_2","first-page":"1481","article-title":"Concentrations of lamotrigine in a mother on lamotrigine treatment and her newborn child","volume":"5","author":"Rambeck B","year":"1997","journal-title":"Eur J Clin Pharmacol"},{"key":"e_1_2_12_73_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01489.x"},{"issue":"2","key":"e_1_2_12_74_2","first-page":"21","article-title":"Lamotrigine levels in plasma and breast milk in nursing women and their infant","volume":"39","author":"Ohman I","year":"1998","journal-title":"Epilepsia"},{"key":"e_1_2_12_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00232.x"},{"key":"e_1_2_12_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2003.11.018"},{"key":"e_1_2_12_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-005-0070-3"},{"key":"e_1_2_12_78_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.14301.x"},{"key":"e_1_2_12_79_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1993.tb04106.x"},{"key":"e_1_2_12_80_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1994.tb05952.x"},{"issue":"7","key":"e_1_2_12_81_2","first-page":"2.232","article-title":"Report of a single\u2013centre pregnancy registry of AEDS: focus on outcomes with oxcarbazepine (Trileptal\u00ae)","volume":"43","author":"Rabinowicz AL","year":"2002","journal-title":"Epilepsia"},{"key":"e_1_2_12_82_2","first-page":"321.00","volume-title":"Pregnancy outcome in women taking oxcarbazepine for epilepsy","author":"Isojarvi JIT","year":"2003"},{"key":"e_1_2_12_83_2","first-page":"318.00","volume-title":"Oxcarbazepine (Trileptal\u00ae) and pregnancy outcomes: report of a single\u2010centre, retrospective study","author":"Peltola JT","year":"2003"},{"key":"e_1_2_12_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2003.11.020"},{"key":"e_1_2_12_85_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.63.10_suppl_4.S13"},{"key":"e_1_2_12_86_2","volume-title":"Pregnancy outcomes with oxcarbazepine (Trileptal\u00ae) therapy: a review of Novartis safety database","author":"Lassiter A","year":"2004"},{"issue":"8","key":"e_1_2_12_87_2","first-page":"158","article-title":"Evaluation of teratogenic effects of new generation of antiepileptic drugs","volume":"43","author":"J\u0119drejczac J","year":"2002","journal-title":"Epilepsia"},{"key":"e_1_2_12_88_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2000.90193a.x"},{"key":"e_1_2_12_89_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1994.tb05944.x"},{"key":"e_1_2_12_90_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000163771.96962.1F"},{"key":"e_1_2_12_91_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00540963"},{"key":"e_1_2_12_92_2","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200323100-00008"},{"key":"e_1_2_12_93_2","first-page":"103.00","volume-title":"Infant neurodevelopment following pre\u2010 and postnatal exposure to oxcarbazepine","author":"Gentile S","year":"2005"},{"key":"e_1_2_12_94_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0406"},{"key":"e_1_2_12_95_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0114c"},{"key":"e_1_2_12_96_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200004000-00036"},{"key":"e_1_2_12_97_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D326"},{"key":"e_1_2_12_98_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105049044"},{"key":"e_1_2_12_99_2","first-page":"137","article-title":"Olanzapine and pregnancy","volume":"142","author":"Nagy A","year":"2001","journal-title":"Orv Hetil"},{"key":"e_1_2_12_100_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001150170023"},{"key":"e_1_2_12_101_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1Z428"},{"key":"e_1_2_12_102_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1614.2001.0971e.x"},{"key":"e_1_2_12_103_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-31519"},{"key":"e_1_2_12_104_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200008000-00002"},{"key":"e_1_2_12_105_2","unstructured":"Eli Lilly Research Laboratories. Data on file."},{"key":"e_1_2_12_106_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195804172581601"},{"key":"e_1_2_12_107_2","first-page":"69","volume-title":"Reproductive and Perinatal Epidemiology","author":"Kerly M","year":"1991"},{"key":"e_1_2_12_108_2","first-page":"269","article-title":"Estimating the probability of spontaneous abortion in the presence of induced abortion and vice versa","volume":"107","author":"Hammerslough CR","year":"1992","journal-title":"Public Health Rep"},{"key":"e_1_2_12_109_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-7974"},{"key":"e_1_2_12_110_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.8.1342"},{"key":"e_1_2_12_111_2","doi-asserted-by":"publisher","DOI":"10.2190\/MTXF-06M3-DBFE-WPQJ"},{"key":"e_1_2_12_112_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674370204701008"},{"issue":"1","key":"e_1_2_12_113_2","first-page":"185","article-title":"Olanzapine use during breast\u2010feeding","volume":"53","author":"Goldstein DJ","year":"2003","journal-title":"Schizophr Res"},{"key":"e_1_2_12_114_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000106225.36344.58"},{"key":"e_1_2_12_115_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145702003012"},{"key":"e_1_2_12_116_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.8.1428"},{"key":"e_1_2_12_117_2","volume-title":"Quetiapine is effective in the treatment of bipolar affective disorder during pregnancy","author":"Balke LD","year":"2001"},{"key":"e_1_2_12_118_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.4.674"},{"key":"e_1_2_12_119_2","first-page":"381","article-title":"Quetiapina in gravidanza: caso clinico","volume":"9","author":"Pace A","year":"2003","journal-title":"Gio Ital Ost Ginecol"},{"key":"e_1_2_12_120_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.3.588-a"},{"key":"e_1_2_12_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2004.01.010"},{"key":"e_1_2_12_122_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.9.1715-a"},{"issue":"3","key":"e_1_2_12_123_2","first-page":"S407","article-title":"Quetiapine monotherapy in post partum onset bipolar disorder with a mixed affective state","volume":"15","author":"Ritz S","year":"2005","journal-title":"Eur Neuropsych Pharamacol"},{"key":"e_1_2_12_124_2","volume-title":"Arch Women's Mental Health","author":"Gentile S","year":"2006"},{"key":"e_1_2_12_125_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1975.01760200064006"},{"key":"e_1_2_12_126_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1986.tb06223.x"},{"key":"e_1_2_12_127_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1988.tb10637.x"},{"key":"e_1_2_12_128_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.176.6.523"},{"key":"e_1_2_12_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(02)00102-7"},{"key":"e_1_2_12_130_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.1.79"},{"key":"e_1_2_12_131_2","first-page":"159","article-title":"Gender differences in bipolar disorder alcohol abuse comorbidity","volume":"12","author":"Frye MA","year":"2000","journal-title":"Acta Neuropsychiatr"},{"key":"e_1_2_12_132_2","doi-asserted-by":"publisher","DOI":"10.1192\/pb.24.6.229"},{"key":"e_1_2_12_133_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.4.880"},{"key":"e_1_2_12_134_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-7197-7_48"},{"key":"e_1_2_12_135_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000162854.67767.06"},{"key":"e_1_2_12_136_2","doi-asserted-by":"publisher","DOI":"10.1597\/04-031.1"},{"issue":"2","key":"e_1_2_12_137_2","first-page":"59","article-title":"Evidence\u2010based mental health use of anticonvulsivants during pregnancy","volume":"37","author":"Gagliardi JP","year":"2003","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_12_138_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-002-0003-7"},{"issue":"9","key":"e_1_2_12_139_2","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1096\/fj.04-3425fje","article-title":"Association of valproate\u2010induced teratogenesis with histone deacetylase inhibition in vivo","volume":"19","author":"Gurvich N","year":"2005","journal-title":"FASEB J"},{"key":"e_1_2_12_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90133-A"},{"key":"e_1_2_12_141_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000154514.82948.69"},{"key":"e_1_2_12_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)90636-7"},{"key":"e_1_2_12_143_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb02604.x"},{"key":"e_1_2_12_144_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.4.549"},{"key":"e_1_2_12_145_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.15104.x"},{"key":"e_1_2_12_146_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.451101.x"},{"key":"e_1_2_12_147_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.61.6_suppl_2.S35"},{"key":"e_1_2_12_148_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X43640"},{"key":"e_1_2_12_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70224-6"},{"issue":"3","key":"e_1_2_12_150_2","first-page":"28","article-title":"Tolerability profiles of atypical antipsychotics in the treatment of bipolar disorders","volume":"66","author":"McIntyre RS","year":"2005","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_12_151_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20013"},{"key":"e_1_2_12_152_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.1.136"},{"key":"e_1_2_12_153_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.3.776"},{"key":"e_1_2_12_154_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.3.3.221"},{"key":"e_1_2_12_155_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v61n0304"},{"key":"e_1_2_12_156_2","first-page":"67","volume-title":"Drugs and human lactation: a comprehensive guide to the content and consequences of drugs, micronutrients, radiopharmaceuticals, and environmental and occupational chemicals in human milk","author":"Bennet PN","year":"1996"},{"key":"e_1_2_12_157_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200022060-00002"},{"key":"e_1_2_12_158_2","doi-asserted-by":"publisher","DOI":"10.1080\/00926230390195524"},{"key":"e_1_2_12_159_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n1102"},{"key":"e_1_2_12_160_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.63.10_suppl_4.S13"},{"key":"e_1_2_12_161_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1614.2005.01650.x"},{"issue":"3","key":"e_1_2_12_162_2","first-page":"CD004848","article-title":"Common antiepileptic drugs in pregnancy in women with epilepsy","author":"Adab N","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_163_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.00323.x"},{"key":"e_1_2_12_164_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.144.9.1241b"},{"key":"e_1_2_12_165_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(66)80045-8"},{"key":"e_1_2_12_166_2","unstructured":"AltshulerL RichardM YonkersK.Treating bipolar disorder during pregnancy. How to protect the fetus from the risk of malformations and both mother and offspring from the danger of relapse. Available on:http:\/\/www.healthyplace.com\/communities\/bipolar\/women_pregnancy_5.usp. Accessed July 17 2005."},{"key":"e_1_2_12_167_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1975.01760200064006"},{"key":"e_1_2_12_168_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1960.03590120014002"},{"key":"e_1_2_12_169_2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1176\/ajp.153.5.592","article-title":"Pharmacological management of psychiatric illness during pregnancy: dilemmas and guidelines","volume":"153","author":"Altshuler L","year":"1996","journal-title":"Am J Psychiatry"},{"key":"e_1_2_12_170_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0307"},{"key":"e_1_2_12_171_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D485"},{"key":"e_1_2_12_172_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7085.932"},{"issue":"3","key":"e_1_2_12_173_2","first-page":"52","article-title":"Interpersonal psychotherapy for antenatal and postpartum depression","volume":"11","author":"Segre LS","year":"2004","journal-title":"Primary Psychiatry"},{"issue":"4","key":"e_1_2_12_174_2","first-page":"1","article-title":"Practice guideline for the treatment of patients with bipolar disorder (revision)","volume":"159","author":"American Psychiatric Association","year":"2002","journal-title":"Am J Psychiatry"},{"key":"e_1_2_12_175_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200528020-00005"},{"key":"e_1_2_12_176_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.4.2.273"},{"key":"e_1_2_12_177_2","unstructured":"GlaxoSmithKline.Important information for prescribers about paroxetine and pregnancy. Available on:http:\/\/www.gsk.com\/media\/paroxetine_pregnancy.pdf. Accessed: October 29 2005."},{"key":"e_1_2_12_178_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.164.4.549"},{"key":"e_1_2_12_179_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E547"},{"key":"e_1_2_12_180_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.7.720"},{"key":"e_1_2_12_181_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200528070-00002"},{"key":"e_1_2_12_182_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200519070-00004"},{"key":"e_1_2_12_183_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.19.2372"},{"key":"e_1_2_12_184_2","first-page":"444","article-title":"Use of electroconvulsive therapy during pregnancy","volume":"45","author":"Miller LJ.","year":"1994","journal-title":"Hosp Community Psychiatry"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-5618.2006.00295.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-5618.2006.00295.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T11:09:58Z","timestamp":1696936198000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-5618.2006.00295.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,12]]},"references-count":183,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1399-5618.2006.00295.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-5618.2006.00295.x","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,12]]}}}