{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:55:24Z","timestamp":1791860124633,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T00:00:00Z","timestamp":1142380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:\u2002<\/jats:bold>\n                    Despite promising new therapies, bipolar depression remains difficult to treat. Up to half of patients do not respond adequately to currently approved treatments. This study evaluated the efficacy of adjunctive inositol for bipolar depression.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    Seventeen participants with DSM\u2010IV criteria for bipolar depression and a 17\u2010item Hamilton Rating Scale for Depression (HRSD) \u226515 on proven therapeutic levels of lithium or valproate for &gt;2\u2003weeks were randomized to receive double\u2010blind inositol or placebo for 6\u2003weeks. At the end of double\u2010blind treatment, subjects were eligible for an 8\u2010week open\u2010label trial of inositol.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Response was defined\n                    <jats:italic>a priori<\/jats:italic>\n                    as &gt;50% reduction in the HRSD and a Clinical Global Impression of 1\u20132. Four of nine subjects (44%) on inositol and zero of eight subjects on placebo met response criteria (p\u2003=\u20030.053). There was no difference between groups in the average change score for the HRSD or Young Mania Rating Scale (YMRS). Response to inositol was highly variable. Of nine subjects randomized to inositol, two had &gt;50% worsening in HRSD scores at the end of treatment, three had no change and four had &gt;50% improvement. Those who had worsening in depressive symptoms on inositol had significantly higher scores at baseline on the YMRS total score and irritability, disruptive\/aggressive behavior and unkempt appearance items.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    There was a trend for more subjects on inositol to show improvement in bipolar depression symptoms, but, on average, inositol was not more effective than placebo as an adjunct for bipolar depression. Baseline levels of anger or hostility may be predictive of clinical response to inositol.\n                  <\/jats:p>","DOI":"10.1111\/j.1399-5618.2006.00303.x","type":"journal-article","created":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T04:46:54Z","timestamp":1142398014000},"page":"168-174","source":"Crossref","is-referenced-by-count":63,"title":["Inositol augmentation of lithium or valproate for bipolar depression"],"prefix":"10.1111","volume":"8","author":[{"given":"Evins","family":"A 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