{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T22:42:40Z","timestamp":1792363360366,"version":"4.4.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T00:00:00Z","timestamp":1142380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:\u2002<\/jats:bold>\n                    The effect of lamotrigine maintenance therapy on body weight was assessed retrospectively in analyses of data from two double\u2010blind, placebo\u2010 and lithium\u2010controlled, 18\u2010month studies in patients with bipolar I disorder (n\u2003=\u2003227 for lamotrigine, 190 for placebo, 166 for lithium).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    Endpoints included mean change in weight, the percentage of patients with \u22657% change (increase, decrease, fluctuation) in weight, and the percentage of patients with weight\u2010related adverse events during double\u2010blind treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Mean weight remained stable during maintenance therapy with lamotrigine. In a mixed\u2010model repeated\u2010measures analysis, mean changes in weight (kg) at week 52 were \u22121.2 with lamotrigine, +0.2 with placebo, and +2.2 with lithium [estimated difference (95% CI) lamotrigine minus placebo\u2003=\u2003\u22121.3 (\u22123.6, 0.9), p\u2003=\u20030.237; lithium minus placebo\u2003=\u2003+2.0 (\u22120.3, 4.4), p\u2003=\u20030.094; lithium minus lamotrigine\u2003=\u2003+3.4 (1.4, 5.4), p\u2003&lt;\u20030.001]. Analyses were truncated at week 52 because of the high incidence of missing data at later time points. The percentages of patients with a \u22657% weight gain, during randomized treatment, were 10.9%, 7.6% and 11.8% for the lamotrigine, placebo, and lithium groups, respectively. The percentages of patients with a \u22657% weight loss, during randomized treatment, were 12.1%, 11.5%, and 5.1% for the lamotrigine, placebo, and lithium groups, respectively. The percentage of patients with a \u22657% weight loss did not significantly differ between lamotrigine and placebo but was significantly higher with lamotrigine than lithium. The incidences of \u22657% weight changes and of weight changes reported as adverse events were comparable between active treatments and placebo.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:\u2002<\/jats:bold>\n                    Lamotrigine was associated with stable body weight during 1\u2003year of treatment and was comparable to placebo in mean weight change, incidence of clinically significant weight change, and incidence of weight changes reported as adverse events in patients with bipolar disorder. Lithium was associated with weight gain, but the magnitude of lithium\u2010associated weight gain was lower in the current analysis than in previous studies.\n                  <\/jats:p>","DOI":"10.1111\/j.1399-5618.2006.00308.x","type":"journal-article","created":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T04:46:54Z","timestamp":1142398014000},"page":"175-181","source":"Crossref","is-referenced-by-count":70,"title":["Effects of lamotrigine and lithium on body weight during maintenance treatment of bipolar I disorder"],"prefix":"10.1111","volume":"8","author":[{"given":"Gary","family":"Sachs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Bowden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R","family":"Calabrese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence","family":"Ketter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Bentley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0506"},{"issue":"1","key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1097\/01.jcp.0000084037.22282.a3","article-title":"The implications of weight changes with antipsychotic treatment","volume":"23","author":"Sussman N","year":"2003","journal-title":"J Clin Psychopharmacol"},{"key":"e_1_2_6_4_2","volume-title":"The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity","author":"US Department of Health and Human Services","year":"2001"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520300035033"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009460"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009256"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n1205"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(02)00498-X"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0906"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.4.392"},{"issue":"8","key":"e_1_2_6_12_2","first-page":"22","article-title":"Weight gain in the treatment of mood disorders","volume":"64","author":"Aronne LJ","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0321"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-5618.2006.00308.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-5618.2006.00308.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T07:23:08Z","timestamp":1764228188000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-5618.2006.00308.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,15]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1399-5618.2006.00308.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-5618.2006.00308.x","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,15]]}}}