{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T19:39:15Z","timestamp":1794253155049,"version":"4.9.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T00:00:00Z","timestamp":1147392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> Recent studies have shown that outcome in mania is worse than previously thought. Such studies have been conducted in selected samples with restrictive measures of outcome. We aimed to explore outcome and its predictors in a catchment area sample of first\u2010episode psychotic mania of DSM\u2010III\u2010R bipolar I disorder.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Prospective 6 and 12\u2003months follow\u2010up was conducted with 87 DSM\u2010III\u2010R first\u2010episode psychotic mania patients admitted to Early Psychosis Prevention and Intervention Centre between 1989 and 1997. Syndromic and symptomatic outcome were determined with the Brief Psychiatric Rating Scale; functional outcome with the Quality of Life Scale and Premorbid Adjustment Scale subitems.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Symptomatic outcome was assessed in 67 patients at 6\u2003months and 61 patients at 12\u2003months, and functional outcome in 56 patients at 6\u2003months and 49 patients at 12\u2003months. Logistic regressions were conducted on 46 and 43 patients, respectively, to explore predictors of outcome. While 90% of patients achieved syndromic recovery at 6 and 12\u2003months, 40% had not recovered symptomatically at 6 and 12\u2003months, still presenting with anxiety or depression. A total of 66% of patients at 6\u2003months and 61% of patients at 12\u2003months failed to return to previous level of functioning. Age at intake, family history of affective disorder, illicit drug use and functional recovery at 6\u2003months predicted functional outcome at 12\u2003months.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> This study confirms poor symptomatic and functional outcome after first\u2010episode psychotic mania. It suggests possible usefulness of early intervention strategies in bipolar disorders and need for developing specific interventions addressing anxiety, depression and substance abuse comorbidity.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2006.00315.x","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T16:04:42Z","timestamp":1147449882000},"page":"221-231","source":"Crossref","is-referenced-by-count":84,"title":["Symptomatic and functional outcome 12\u2003months after a first episode of psychotic mania: barriers to recovery in a catchment area 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