{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:58:03Z","timestamp":1791071883153,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"5p2","license":[{"start":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T00:00:00Z","timestamp":1161043200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> This study determined the clinical predictors of suicidal behavior during a 2\u2010year follow\u2010up of patients with bipolar disorder presenting with a major depressive episode (MDE).<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Sixty four patients with DSM\u2010III\u2010R bipolar disorder were assessed at presentation for treatment of an MDE. Correlates of past suicidal behavior were determined by comparing patients with and without a history of suicide attempts using a <jats:italic>t<\/jats:italic>\u2010test, Wilcoxon test or chi\u2010squared test of independence on individual explanatory variables. Putative predictors of attempts during the follow\u2010up period were tested separately using Cox proportional hazards regression analysis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Twelve of 64 patients had at least one suicide attempt in the follow\u2010up period, five of them attempted in the first 2\u2003months and seven around or shortly after the 1\u2010year follow\u2010up visit. All attempters had a history of past suicide attempts. Most predictors of future suicidal behavior were correlates of past suicidal behavior. Family history of suicide acts and comorbid borderline personality disorder predicted early attempts, while younger age, high hostility scores, number of past attempts, subjective pessimism as reflected in depression and suicidal ideation, and few reported reasons for living predicted suicidal acts during the whole period.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In this data set of bipolar patients we noted an intriguing picture of two clusters of suicide attempts. Hostility was the strongest risk factor. These findings may have implications in both the identification of at\u2010risk patients and the timing of clinical interventions including aggressive pharmacotherapeutic prophylaxis to prevent relapse or recurrence of depressive symptomatology.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2006.00340.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T16:06:57Z","timestamp":1161187617000},"page":"586-595","source":"Crossref","is-referenced-by-count":92,"title":["Clinical predictors of suicidal acts after major depression in bipolar disorder: a prospective study"],"prefix":"10.1111","volume":"8","author":[{"given":"Hanga","family":"Galfalvy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A","family":"Oquendo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J","family":"Carballo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Sher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F","family":"Grunebaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainsley","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"John Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,17]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Manic\u2010Depressive Illness","author":"Goodwin FK","year":"1990"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00295-2"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(00)90501-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1996.tb10656.x"},{"key":"e_1_2_6_6_2","volume-title":"American College of Neuropsychopharmacology Annual Meeting, San Juan, Puerto Rico","author":"Oquendo M","year":"2004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0503"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01239-2"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2003.00017.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v60n1103"},{"issue":"2","key":"e_1_2_6_11_2","first-page":"63","article-title":"Suicide attempts in major affective disorder patients with comorbid substance use disorders","volume":"60","author":"Tondo L","year":"1999","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.12.2048"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00129-9"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0409"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00025-7"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2003.00050.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00066-4"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0602"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.144.3.309"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.9.914"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00377-9"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1521\/suli.32.1.10.22183"},{"key":"e_1_2_6_23_2","first-page":"17","article-title":"Outcome of a clinical cohort of unipolar, bipolar and schizoaffective patients. 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