{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:46:44Z","timestamp":1791424004864,"version":"4.3.3"},"reference-count":268,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T00:00:00Z","timestamp":1164585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>\n                    <jats:bold>Context:\u2002<\/jats:bold>\n                    Bipolar\/panic comorbidity has been observed in clinical, community and familial samples. As both are episodic disorders of affect regulation, the common pathophysiological mechanism is likely to involve deficits in amygdala\u2010mediated, plasticity\u2010dependent emotional conditioning.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Evidence:\u2002<\/jats:bold>\n                    Neuronal genesis and synaptic remodeling occur in the amygdala; bipolar and panic disorders have both been associated with abnormality in the amygdala and related structures, as well as in molecules that modulate plasticity, such as serotonin, norepinephrine, brain\u2010derived neurotrophic factor (BDNF) and corticotrophin releasing factor (CRF). These biological elements are involved in behavioral conditioning to threat and reward.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Model:\u2002<\/jats:bold>\n                    Panic attacks resemble the normal acute fear response, but are abnormally dissociated from any relevant threat. Abnormal reward\u2010seeking behavior is central to both manic and depressive syndromes. Appetites can be elevated or depressed; satisfaction of a drive may fail to condition future behavior. These dissociations may be the result of deficits in plasticity\u2010dependent processes of conditioning within different amygdala subregions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    This speculative model may be a useful framework with which to connect molecular, cellular, anatomic and behavioral processes in panic and bipolar disorders. The primary clinical implication is that behavioral treatment may be critical to restore function in some bipolar patients who respond only partially to medications.\n                  <\/jats:p>","DOI":"10.1111\/j.1399-5618.2006.00356.x","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T05:59:43Z","timestamp":1164607183000},"page":"648-664","source":"Crossref","is-referenced-by-count":37,"title":["Panic comorbidity with bipolar disorder: what is the manic\u2013panic connection?"],"prefix":"10.1111","volume":"8","author":[{"given":"Dean F","family":"MacKinnon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Zamoiski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,27]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7407.158"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1972.01750190059011"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770300115013"},{"key":"e_1_2_9_5_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1192\/S0007125000298425","article-title":"Comorbidity and boundaries of affective disorders with anxiety disorders and substance misuse: results of an international task force","volume":"30","author":"Merikangas KR","year":"1996","journal-title":"Br J Psychiatry"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.2307\/3002000"},{"key":"e_1_2_9_7_2","first-page":"935","article-title":"Models of comorbidity for multifactorial disorders","volume":"57","author":"Neale MC","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_9_8_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1192\/S0007125000298358","article-title":"What is comorbidity \u2013 fact or artefact","volume":"30","author":"Wittchen HU","year":"1996","journal-title":"Br J Psychiatry"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.10.905"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00299-8"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(97)00109-1"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(96)01405-X"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0316"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.149.4.554"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0813"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.3.420"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(93)90101-O"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674379403900205"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0507"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674370104600902"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.2.280"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00398-6"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00309-3"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199504000-00012"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00120.x"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/00048679809073872"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00299-5"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.1.30"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.9.1696"},{"key":"e_1_2_9_30_2","first-page":"1384","article-title":"Evidence for linkage of bipolar disorder to chromosome 18 with a parent\u2010of\u2010origin effect","volume":"57","author":"Stine OC","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_9_31_2","first-page":"829","article-title":"Bipolar disorder and panic disorder in families: an analysis of chromosome 18 data","volume":"155","author":"MacKinnon DF","year":"1998","journal-title":"Am J Psychiatry"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.1.23"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2006.00283.x"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2001.030302.x"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00091-5"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(93)90017-V"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.173.6.501"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(84)90027-4"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2903551"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/361031a0"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10107"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/02724990344000097"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01546-9"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.23.1.155"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(00)26011-1"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.2.195"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5492-03.2004"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.07.012"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00833.x"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01969-X"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00338-4"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858403259955"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(93)90122-7"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00302-3"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.106.2.274"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.12.034"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00426-3"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.05.033"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(80)90006-4"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90146-X"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90245-9"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-198212000-00002"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19991001)58:1<42::AID-JNR6>3.0.CO;2-L"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01731-X"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1990.tb06460.x"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6394(1996)4:3<139::AID-DA7>3.0.CO;2-B"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00319-6"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5276.749"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2002.40101.x"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.18.030195.001111"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90568-7"},{"key":"e_1_2_9_72_2","first-page":"323","article-title":"Neurogenesis in septum, amygdala and hippocampus in the marsupial brushtailed possum (Trichosurus vulpecula)","volume":"57","author":"Sanderson KJ","year":"1997","journal-title":"Rev Bras Biol"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.172403999"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00012.2004"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.03.001"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2004.00328.x"},{"key":"e_1_2_9_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00358-X"},{"key":"e_1_2_9_78_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083328"},{"key":"e_1_2_9_79_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.5.2642"},{"key":"e_1_2_9_80_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02093.x"},{"key":"e_1_2_9_81_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5377-03.2004"},{"key":"e_1_2_9_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)35012-X"},{"key":"e_1_2_9_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02793-8"},{"key":"e_1_2_9_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00195-8"},{"key":"e_1_2_9_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01507-X"},{"key":"e_1_2_9_86_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.1.34"},{"key":"e_1_2_9_87_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.12.1201"},{"key":"e_1_2_9_88_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000159948.75136.0d"},{"key":"e_1_2_9_89_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-5618.2003.00087.x"},{"key":"e_1_2_9_90_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.7.734"},{"key":"e_1_2_9_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00036-3"},{"key":"e_1_2_9_92_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2003000700014"},{"key":"e_1_2_9_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001585"},{"key":"e_1_2_9_94_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1121189X00005558"},{"key":"e_1_2_9_95_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2004.00413.x"},{"key":"e_1_2_9_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000370"},{"key":"e_1_2_9_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00109-X"},{"key":"e_1_2_9_98_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13290"},{"key":"e_1_2_9_99_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07098.x"},{"key":"e_1_2_9_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001579"},{"key":"e_1_2_9_101_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.7.1256"},{"key":"e_1_2_9_102_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.12.1115"},{"key":"e_1_2_9_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00009-8"},{"key":"e_1_2_9_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00177-X"},{"key":"e_1_2_9_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(99)00054-8"},{"key":"e_1_2_9_106_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.8.781"},{"key":"e_1_2_9_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2003.10.010"},{"key":"e_1_2_9_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)00962-8"},{"key":"e_1_2_9_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(93)90004-W"},{"key":"e_1_2_9_110_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810060013003"},{"key":"e_1_2_9_111_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.8.1180"},{"key":"e_1_2_9_112_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200112210-00020"},{"key":"e_1_2_9_113_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200303030-00006"},{"key":"e_1_2_9_114_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200506210-00010"},{"key":"e_1_2_9_115_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb05830.x"},{"key":"e_1_2_9_116_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026021307833"},{"key":"e_1_2_9_117_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2.1.34"},{"key":"e_1_2_9_118_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.1.66"},{"key":"e_1_2_9_119_2","first-page":"13","article-title":"Dexamethasone Suppression Test: a review of contemporary confusion","volume":"46","author":"Carroll BJ","year":"1985","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_9_120_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5613.285"},{"key":"e_1_2_9_121_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790350067012"},{"key":"e_1_2_9_122_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.184.6.496"},{"key":"e_1_2_9_123_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1600001"},{"key":"e_1_2_9_124_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0065-1591.2000.acp29[dash]04.x"},{"key":"e_1_2_9_125_2","doi-asserted-by":"publisher","DOI":"10.1038\/520"},{"key":"e_1_2_9_126_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-01-00193.2002"},{"key":"e_1_2_9_127_2","first-page":"80","article-title":"Stimulation response to corticotropin\u2010releasing hormone (CRH) in patients with depression, alcoholism and panic disorder","volume":"16","author":"Holsboer F","year":"1987","journal-title":"Horm Metab Res"},{"key":"e_1_2_9_128_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291799008727"},{"key":"e_1_2_9_129_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007020070062"},{"key":"e_1_2_9_130_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830040059010"},{"key":"e_1_2_9_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.08.005"},{"key":"e_1_2_9_132_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.2.130"},{"key":"e_1_2_9_133_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810020037007"},{"key":"e_1_2_9_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01250-1"},{"key":"e_1_2_9_135_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.3.454"},{"key":"e_1_2_9_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(01)00075-0"},{"key":"e_1_2_9_137_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0001-37652005000300009"},{"key":"e_1_2_9_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(87)90058-8"},{"key":"e_1_2_9_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(99)00029-3"},{"key":"e_1_2_9_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2003.10.005"},{"key":"e_1_2_9_141_2","doi-asserted-by":"publisher","DOI":"10.1002\/da.20062"},{"key":"e_1_2_9_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00058-5"},{"key":"e_1_2_9_143_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.10.1014"},{"key":"e_1_2_9_144_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.77.6.3013"},{"key":"e_1_2_9_145_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1058"},{"key":"e_1_2_9_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(03)00085-6"},{"key":"e_1_2_9_147_2","doi-asserted-by":"publisher","DOI":"10.1038\/417282a"},{"key":"e_1_2_9_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(04)59006-2"},{"key":"e_1_2_9_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.08.001"},{"key":"e_1_2_9_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(04)59016-5"},{"key":"e_1_2_9_151_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.15.8191"},{"key":"e_1_2_9_152_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.21.5887"},{"key":"e_1_2_9_153_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858404272255"},{"key":"e_1_2_9_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.04.010"},{"key":"e_1_2_9_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.02.003"},{"key":"e_1_2_9_156_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.8.804"},{"key":"e_1_2_9_157_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.08.003"},{"key":"e_1_2_9_158_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-003-0086-1"},{"key":"e_1_2_9_159_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077362"},{"key":"e_1_2_9_160_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.04.018"},{"key":"e_1_2_9_161_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1999.00337.x"},{"key":"e_1_2_9_162_2","first-page":"250","article-title":"The involvement of serotonin in regulation of pituitary\u2013adrenocortical function","volume":"13","author":"Fuller RW","year":"1992","journal-title":"Front Neuroendocrinol"},{"key":"e_1_2_9_163_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb49922.x"},{"key":"e_1_2_9_164_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.11.040"},{"key":"e_1_2_9_165_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(84)90261-4"},{"key":"e_1_2_9_166_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.06.035"},{"key":"e_1_2_9_167_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00703-9"},{"key":"e_1_2_9_168_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.02.030179.002445"},{"key":"e_1_2_9_169_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.8.787"},{"key":"e_1_2_9_170_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.122.5.509"},{"key":"e_1_2_9_171_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2003.12.004"},{"key":"e_1_2_9_172_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810170011002"},{"key":"e_1_2_9_173_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.176.2.182"},{"key":"e_1_2_9_174_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(00)00117-7"},{"key":"e_1_2_9_175_2","doi-asserted-by":"publisher","DOI":"10.1177\/02698811030173002"},{"key":"e_1_2_9_176_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1972.01750270014002"},{"key":"e_1_2_9_177_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(94)00094-P"},{"key":"e_1_2_9_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)91201-7"},{"key":"e_1_2_9_179_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.115.2.358"},{"key":"e_1_2_9_180_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197208032870508"},{"key":"e_1_2_9_181_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.10.1785"},{"key":"e_1_2_9_182_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000385"},{"key":"e_1_2_9_183_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000410"},{"key":"e_1_2_9_184_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960920)67:5<468::AID-AJMG5>3.0.CO;2-G"},{"key":"e_1_2_9_185_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.1.113"},{"key":"e_1_2_9_186_2","doi-asserted-by":"publisher","DOI":"10.2165\/00129785-200505010-00004"},{"key":"e_1_2_9_187_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1193"},{"key":"e_1_2_9_188_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.4.621"},{"key":"e_1_2_9_189_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.10013"},{"key":"e_1_2_9_190_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000772"},{"key":"e_1_2_9_191_2","doi-asserted-by":"publisher","DOI":"10.3109\/15622970009150583"},{"key":"e_1_2_9_192_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-005-0012-9"},{"key":"e_1_2_9_193_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30104"},{"key":"e_1_2_9_194_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500156"},{"key":"e_1_2_9_195_2","doi-asserted-by":"publisher","DOI":"10.1080\/15622970410029927"},{"key":"e_1_2_9_196_2","first-page":"41","article-title":"Lack of relationship between CO2 reactivity and serotonin transporter gene regulatory region polymorphism in panic disorder","volume":"129","author":"Perna G","year":"2004","journal-title":"Am J Med"},{"key":"e_1_2_9_197_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071829"},{"key":"e_1_2_9_198_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1366"},{"key":"e_1_2_9_199_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.02.070"},{"key":"e_1_2_9_200_2","doi-asserted-by":"publisher","DOI":"10.1038\/416396a"},{"key":"e_1_2_9_201_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1101678"},{"key":"e_1_2_9_202_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07090.x"},{"key":"e_1_2_9_203_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.8.715"},{"key":"e_1_2_9_204_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.6.556"},{"key":"e_1_2_9_205_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90079-5"},{"key":"e_1_2_9_206_2","first-page":"e49","article-title":"Signal transduction and genes\u2010to\u2010behaviours pathways in psychiatric diseases","volume":"207","author":"Manji HK","year":"2003","journal-title":"Sci STKE"},{"key":"e_1_2_9_207_2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1055\/s-2003-45138","article-title":"Implications of the neuroprotective effects of lithium for the treatment of bipolar and neurodegenerative disorders","volume":"36","author":"Bauer M","year":"2003","journal-title":"Pharmacopsychiatry"},{"key":"e_1_2_9_208_2","doi-asserted-by":"publisher","DOI":"10.1385\/MN:25:2:191"},{"key":"e_1_2_9_209_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-004-0073-1"},{"key":"e_1_2_9_210_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2004.05.005"},{"key":"e_1_2_9_211_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.99.2.342"},{"key":"e_1_2_9_212_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.09.025"},{"key":"e_1_2_9_213_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.5.6.373"},{"key":"e_1_2_9_214_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00343-8"},{"key":"e_1_2_9_215_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00282-0"},{"key":"e_1_2_9_216_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn875"},{"key":"e_1_2_9_217_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00153.2004"},{"key":"e_1_2_9_218_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.042"},{"key":"e_1_2_9_219_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(97)01214-9"},{"key":"e_1_2_9_220_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07082.x"},{"key":"e_1_2_9_221_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2003.08.008"},{"key":"e_1_2_9_222_2","doi-asserted-by":"publisher","DOI":"10.1038\/35077083"},{"key":"e_1_2_9_223_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09279.x"},{"key":"e_1_2_9_224_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07094.x"},{"key":"e_1_2_9_225_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00288-1"},{"key":"e_1_2_9_226_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(02)00007-6"},{"key":"e_1_2_9_227_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07085.x"},{"key":"e_1_2_9_228_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.09.057"},{"key":"e_1_2_9_229_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199810050-00019"},{"key":"e_1_2_9_230_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07083.x"},{"key":"e_1_2_9_231_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01328-2"},{"key":"e_1_2_9_232_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.108.s417.3.x"},{"key":"e_1_2_9_233_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00300-X"},{"key":"e_1_2_9_234_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.4.493"},{"key":"e_1_2_9_235_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7967(00)00087-5"},{"key":"e_1_2_9_236_2","first-page":"4","article-title":"Toward an integrated neurobiology of panic disorder","volume":"58","author":"Goddard AW","year":"1997","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_9_237_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.9.3.313"},{"key":"e_1_2_9_238_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820160076009"},{"key":"e_1_2_9_239_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0995-910"},{"key":"e_1_2_9_240_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200103000-00006"},{"key":"e_1_2_9_241_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2005.01.009"},{"key":"e_1_2_9_242_2","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.114.1.50"},{"key":"e_1_2_9_243_2","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1001\/archpsyc.62.8.922","article-title":"Disorder\u2010specific neuroanatomical correlates of attentional bias in obsessive\u2013compulsive disorder, panic disorder and hypochondriasis","volume":"62","author":"Van Den Heuvel OA","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"e_1_2_9_244_2","first-page":"37","article-title":"Information\u2010processing deficits and cognitive dysfunction in panic disorder","volume":"30","author":"Ludewig S","year":"2005","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_9_245_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.53.100901.135148"},{"key":"e_1_2_9_246_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01019-2"},{"key":"e_1_2_9_247_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001521"},{"key":"e_1_2_9_248_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00233-9"},{"key":"e_1_2_9_249_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.013"},{"key":"e_1_2_9_250_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00026-X"},{"key":"e_1_2_9_251_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(00)26020-2"},{"key":"e_1_2_9_252_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01383-5"},{"key":"e_1_2_9_253_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524023361961"},{"key":"e_1_2_9_254_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.09.001"},{"key":"e_1_2_9_255_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-004-0460-y"},{"key":"e_1_2_9_256_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674370404901204"},{"key":"e_1_2_9_257_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2005.02.005"},{"key":"e_1_2_9_258_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.10.1975"},{"key":"e_1_2_9_259_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.03.007"},{"key":"e_1_2_9_260_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09278.x"},{"key":"e_1_2_9_261_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09270.x"},{"key":"e_1_2_9_262_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.6.601"},{"key":"e_1_2_9_263_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3283936"},{"key":"e_1_2_9_264_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.03.004"},{"key":"e_1_2_9_265_2","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.2003.14.3.253"},{"key":"e_1_2_9_266_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00058-7"},{"key":"e_1_2_9_267_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.03.015"},{"key":"e_1_2_9_268_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199211000-00006"},{"key":"e_1_2_9_269_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2001.30504.x"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-5618.2006.00356.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-5618.2006.00356.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T06:25:51Z","timestamp":1696919151000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-5618.2006.00356.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,27]]},"references-count":268,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1399-5618.2006.00356.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-5618.2006.00356.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1054765.506691","asserted-by":"object"}]},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,27]]}}}