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It is designed to be used in conjunction with the 2005 CANMAT Guidelines. The recommendations for the management of acute mania remain mostly unchanged. Lithium, valproate and several atypical antipsychotics continue to be recommended as first\u2010line treatments for acute mania. For the management of bipolar depression, new data support quetiapine monotherapy as a first\u2010line option. Lithium and lamotrigine monotherapy, olanzapine plus selective serotonin reuptake inhibitors (SSRI), and lithium or divalproex plus SSRI\/bupropion continue to remain the other first\u2010line options. First\u2010line options in the maintenance treatment of bipolar disorder continue to be lithium, lamotrigine, valproate and olanzapine. There is recent evidence to support the combination of olanzapine and fluoxetine as a second\u2010line maintenance therapy for bipolar depression. New data also support quetiapine monotherapy as a second\u2010line option for the management of acute bipolar II depression. 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