{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T09:57:27Z","timestamp":1794563847164,"version":"4.9.1"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,8,2]],"date-time":"2007-08-02T00:00:00Z","timestamp":1186012800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives:\u2002<\/jats:bold>\n                    To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression\/mania ratios in patients with bipolar I versus bipolar II disorder.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    Clinician\u2010adjusted self\u2010ratings of mood were completed daily for one\u2003year for naturalistically treated outpatients with bipolar I (n\u2003=\u2003405) or bipolar II (n\u2003=\u2003102) disorder. Ratings were analyzed for mean time spent euthymic, depressed, manic, hypomanic, and cycling, and the percentages of time spent ill were compared between the two groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Percentages of time spent ill for bipolar I versus II patients were: euthymia 47.7% versus 50.2%; depression 36.0% versus 37.0%; hypomania 11.5% versus 9.8%; mania 1.0% versus 0.2%; and cycling 3.7% versus 2.8%. The depression\/mania ratio was 2.9 in the bipolar I and 3.8 in bipolar II sub\u2010groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    Depression represents the predominant abnormal mood state for treated outpatients with bipolar I and II disorder. In contrast to other studies, we found that depression\/mania ratios were of a similar magnitude, suggesting the same tendency towards mood instability in both sub\u2010groups.\n                  <\/jats:p>","DOI":"10.1111\/j.1399-5618.2007.00467.x","type":"journal-article","created":{"date-parts":[[2007,8,2]],"date-time":"2007-08-02T07:14:53Z","timestamp":1186038893000},"page":"531-535","source":"Crossref","is-referenced-by-count":333,"title":["Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder\n                    <sup>1<\/sup>"],"prefix":"10.1111","volume":"9","author":[{"given":"Ralph W","family":"Kupka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori L","family":"Altshuler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem A","family":"Nolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha","family":"Suppes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Luckenbaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele S","family":"Leverich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Frye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Paul E","family":"Keck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L","family":"McElroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Grunze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M","family":"Post","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.6.530"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.3.261"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00324-5"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00430-X"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.7.1273"},{"key":"e_1_2_6_7_2","volume-title":"Structured Clinical Interview for DSM\u2010IV Axis I Disorders: SCID\u2010I\/P (Version 2.0)","author":"First MB","year":"1996"},{"key":"e_1_2_6_8_2","first-page":"48","article-title":"Life charting the course of bipolar disorder","volume":"1","author":"Leverich GS","year":"1996","journal-title":"Curr Rev Mood Anxiety Disord"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291799002810"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800180050009"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-5618.2003.00091.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0610"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-5618.2007.00467.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-5618.2007.00467.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T17:41:01Z","timestamp":1696873261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-5618.2007.00467.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1111\/j.1399-5618.2007.00467.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-5618.2007.00467.x","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}