{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:51:27Z","timestamp":1773294687432,"version":"3.50.1"},"reference-count":62,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold>Objectives:\u2002<\/jats:bold> Patients with bipolar disorder (BD) have an increased risk of obesity as well as psychotropic\u2010associated weight gain. The objective of this study was to compare sibutramine and topiramate as adjunctive treatments for psychotropic\u2010associated weight gain in overweight or obese outpatients with BD.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In this 24\u2010week, open\u2010label, flexible\u2010dose, comparison trial, 46 outpatients with bipolar disorders who had a body mass index (BMI) \u226530\u2003kg\/m<jats:sup>2<\/jats:sup>, or \u226527\u2003kg\/m<jats:sup>2<\/jats:sup> with obesity\u2010related comorbidities, and psychotropic\u2010associated weight gain were randomly assigned to receive sibutramine (n\u2003=\u200318; 5\u201315\u2003mg\/day) or topiramate (n\u2003=\u200328; 25\u2013600\u2003mg\/day). The primary outcome measure was weight loss. Secondary measures included changes in BMI, percent body weight loss, and mood symptoms.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Patients randomized either to sibutramine or topiramate lost comparable amounts of weight (4.1\u2003\u00b1\u20035.7 and 2.8\u2003\u00b1\u20033.5\u2003kg, respectively) and displayed similar rates of weight loss (0.85 and 0.82\u2003kg\/week, respectively). However, only four (22%) patients receiving sibutramine and six (21%) patients receiving topiramate completed the 24\u2010week trial. In addition, the attrition patterns for the two drugs were different, with patients discontinuing topiramate doing so early in treatment and patients discontinuing sibutramine doing so throughout treatment. Also, higher ratings of manic and depressive symptoms significantly increased risk for early topiramate discontinuation compared to that for sibutramine.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Adjunctive sibutramine and topiramate may have comparable weight loss effects in overweight or obese bipolar patients with psychotropic\u2010associated weight gain, but are each associated with similarly high discontinuation rates. In addition, they may have different attrition profiles. Compared to sibutramine, discontinuation of topiramate may be more likely to occur early in treatment and may be more dependent upon manic and depressive symptoms.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2007.00488.x","type":"journal-article","created":{"date-parts":[[2007,6,2]],"date-time":"2007-06-02T04:38:10Z","timestamp":1180759090000},"page":"426-434","source":"Crossref","is-referenced-by-count":56,"title":["A 24\u2010week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders"],"prefix":"10.1111","volume":"9","author":[{"given":"Susan L","family":"McElroy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A","family":"Frye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori L","family":"Altshuler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trisha","family":"Suppes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Hellemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Mintz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Kupka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem","family":"Nolen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele S","family":"Leverich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk D","family":"Denicoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M","family":"Post","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Paul E","family":"Keck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v61n0306"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v62n0614"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0611"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0306"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.1.112"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n1205"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0507"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674370104600308"},{"issue":"18","key":"e_1_2_6_10_2","first-page":"22","article-title":"Weight gain in the treatment of mood disorders","volume":"64","author":"Arrone LJ","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_11_2","first-page":"127","article-title":"Maintenance lithium treatment: side effects and compliance","volume":"50","author":"Gitlin MJ","year":"1989","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0409"},{"key":"e_1_2_6_13_2","volume-title":"Clinical Guidelines of the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. The Evidence Report","year":"1998"},{"key":"e_1_2_6_14_2","volume-title":"Handbook of Obesity. Etiology and Pathophysiology","author":"Bray GA","year":"2004"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000145546.97738.1E"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.9.844"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2005.00234.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2004.40.1.799437"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.9.994"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-7-200504050-00012"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.5.954"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.11.1109"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02850181"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2004.11.008"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(88)90003-6"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00216-8"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145702003000"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0213a"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.284"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.03.053"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnf.0000172994.56028.c3"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.2.255"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00316-9"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(02)80061-3"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(01)00278-0"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2002.01189.x"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0715"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000130556.01373.45"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079904125003665"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2004.10.013"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674370505000705"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.04.003"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2006.00276.x"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000159151.75345.20"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.2.208"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000155828.82456.68"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.3.1.1"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802783"},{"key":"e_1_2_6_49_2","volume-title":"Diagnostic and Statistical Manual","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_50_2","volume-title":"Structured Clinical Interview for DSM\u2010IV Axis I disorders (Research Version, 2\/96 Final)","author":"First MB","year":"1996"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00430-X"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(86)90060-0"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.2.232"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.7.1252"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.10093"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0512"},{"key":"e_1_2_6_58_2","unstructured":"Acomplia Report.http:\/\/www.acompliareport.com\/news\/news\u2010022007.htm(accessed 9 March 2007)."},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199309)14:2<171::AID-EAT2260140207>3.0.CO;2-U"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.5.409"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.11.026"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1452"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-001-0844-z"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-5618.2007.00488.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-5618.2007.00488.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T21:41:09Z","timestamp":1696887669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-5618.2007.00488.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":62,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1111\/j.1399-5618.2007.00488.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-5618.2007.00488.x","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}