{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:50:57Z","timestamp":1760622657362},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T00:00:00Z","timestamp":1207612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Although mental changes are frequent in Wilson\u2019s disease, severe psychiatric disorders occur uncommonly and usually accompany the neurological picture. There are few reports in the literature of Wilson\u2019s disease patients with typical bipolar affective disorder (BPAD).<\/jats:p><jats:p><jats:bold>Case report:\u2002<\/jats:bold> The authors report the case of a patient with Wilson\u2019s disease whose initial manifestation was a manic episode followed by depression. Tremor in the upper limbs appeared one year after the onset of symptoms. The diagnosis of Wilson\u2019s disease was established three years after the first symptoms appeared, based on the neuropsychiatric picture, the detection of Kayser\u2013Fleischer rings and the results of diagnostic tests indicating chronic liver disease and copper excess. <jats:italic>ATP7B<\/jats:italic> genotyping and magnetic resonance imaging of the brain with proton spectroscopy study were also performed. The patient became asymptomatic two years after starting treatment with penicillamine and remained non\u2010symptomatic controlled during the eight\u2010year follow\u2010up period, without any specific treatment for the BPAD.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> To our knowledge, this is a singular report of a case of Wilson\u2019s disease in which a manic episode preceded the onset of neurological symptoms. The association between Wilson\u2019s disease and bipolar disorder is discussed.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2007.00531.x","type":"journal-article","created":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T19:33:12Z","timestamp":1207683192000},"page":"447-450","source":"Crossref","is-referenced-by-count":18,"title":["Mania as the first manifestation of Wilson\u2019s disease"],"prefix":"10.1111","volume":"10","author":[{"given":"Alexandre Costa","family":"Machado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Mitiko","family":"Deguti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Caixeta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Spitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro Tavares","family":"Lucato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egberto Reis","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,8]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/34.4.295"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.146.5.662"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.44.5.438"},{"key":"e_1_2_4_5_2","first-page":"57","article-title":"Neurological manifestations in Wilson\u2019s disease","volume":"214","author":"Machado A","year":"2003","journal-title":"J Neurol Sci"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100720050010"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(97)00016-2"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2004.10.007"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2005000400035"},{"key":"e_1_2_4_10_2","first-page":"1066","article-title":"Proton MR spectroscopy in Wilson\u2019s disease: analysis of 36 cases","volume":"26","author":"Lucato LT","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/514864"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9227"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-005-7910-8"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-5618.2007.00531.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-5618.2007.00531.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T22:37:25Z","timestamp":1696891045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-5618.2007.00531.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,8]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1111\/j.1399-5618.2007.00531.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-5618.2007.00531.x","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,8]]}}}