{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:26:36Z","timestamp":1791894396438,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T00:00:00Z","timestamp":1207612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> Clinical management of bipolar disorder (BPD) patients during pregnancy is a major challenge. The high risk of bipolar depression during pregnancy encourages consideration of lamotrigine (LTG). We therefore compared recurrence risks among pregnant women with BPD treated with LTG to those discontinuing mood stabilizer therapies.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We compared risks and weeks to new DSM\u2010IV illness\u2010episodes among 26 initially clinically stable pregnant women diagnosed with DSM\u2010IV BPD who continued LTG treatment to those discontinuing all mood stabilizer treatment during pregnancy.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The risk of new illness\u2010episodes with LTG was 30% versus 100% after discontinuing mood stabilizers, and survival\u2010computed time\u2010to\u201025%\u2010recurrence was 28.0 versus 2.0\u2003weeks (\u03c7<jats:sup>2\u2003<\/jats:sup>=<jats:sup>\u2003<\/jats:sup>17.3, p\u2003&lt;\u20030.0001; hazard ratio\u2003=\u200312.1; 95% confidence interval\u2003=\u20031.6\u201391.7).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Discontinuing mood stabilizer treatment presents high risks of illness\u2010recurrence among pregnant women diagnosed with BPD. LTG may afford protective effects in pregnancy, and its reported fetal safety compares favorably to other agents used to manage BPD.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2007.00565.x","type":"journal-article","created":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T19:33:12Z","timestamp":1207683192000},"page":"432-436","source":"Crossref","is-referenced-by-count":66,"title":["Lamotrigine in bipolar disorder: efficacy during pregnancy"],"prefix":"10.1111","volume":"10","author":[{"given":"D Jeffrey","family":"Newport","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary N","family":"Stowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele C","family":"Viguera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha R","family":"Calamaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Juric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Page B","family":"Pennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross J","family":"Baldessarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674370204700503"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.4.608"},{"key":"e_1_2_6_4_2","first-page":"745","volume-title":"Essentials of Clinical Psychopharmacology","author":"Newport DJ","year":"2006"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00197-4"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.2.179"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0403"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.06101639"},{"key":"e_1_2_6_9_2","first-page":"461","volume-title":"Goodman and Gilman\u2019s Goodman and Gilman\u2019s The Pharmacological Basis of Therapeutics","author":"Baldessarini RJ","year":"2005"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb46162.x"},{"issue":"7","key":"e_1_2_6_11_2","first-page":"229","article-title":"Gestational lamotrigine monotherapy: congenital malformations and psychomotor development (abstract)","volume":"45","author":"Dominguez\u2010Salgado M","year":"2004","journal-title":"Epilepsia"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-5868(03)00158-9"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2003.00200.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000154515.94346.89"},{"key":"e_1_2_6_15_2","volume-title":"International Lamotrigine Pregnancy Registry: Interim Report (9\/1992\u20133\/2006)","author":"GlaxoSmithKline Corp","year":"2006"},{"key":"e_1_2_6_16_2","first-page":"318","article-title":"Increased risk for non\u2010syndromic cleft palate among infants exposed to lamotrigine during pregnancy (abstract)","volume":"76","author":"Holmes LB","year":"2006","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000227919.81208.b2"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.074203"},{"key":"e_1_2_6_19_2","unstructured":"New York State Department of Health(2005)Congenital Malformations Registry Summary Report: Statistical Summary of Children Born in 1998\u20132001 and Diagnosed Through 2003. 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