{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T17:25:09Z","timestamp":1794504309641,"version":"4.9.1"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T00:00:00Z","timestamp":1277078400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>Chan W\u2010Y, Yang G\u2010L, Chia M\u2010Y, Woon P\u2010S, Lee J, Keefe R, Sitoh Y\u2010Y, Nowinski WL, Sim K. Cortical and subcortical white matter abnormalities in adults with remitted first\u2010episode mania revealed by Tract\u2010Based Spatial Statistics.\u2028Bipolar Disord 2010: 12: 383\u2013389. \u00a9 2010 The Authors. Journal compilation \u00a9 2010 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> Abnormalities of brain white matter have been noted in structural magnetic resonance imaging and diffusion tensor imaging (DTI) studies of bipolar disorder, but there are fewer investigations specifically examining white matter integrity early in the course of illness. In this study, we employed DTI to elucidate white matter changes in adult patients with remitted first\u2010episode mania and hypothesized that first\u2010episode mania was associated with decreased fractional anisotropy in cortical (frontal) and subcortical (thalamus, striatum) white matter as well as white matter tracts (cingulum, corpus callosum).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Diffusion tensor images were acquired from 16 patients with remitted first\u2010episode mania and 16 healthy controls matched for age, gender, handedness, and years of education. Fractional anisotropy and radial and axial diffusivities were analyzed using Tract\u2010Based Spatial Statistics.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Patients had lower fractional anisotropy and higher radial diffusivity in the left anterior frontal white matter, right posterior thalamic radiation, left cingulum, and bilateral sagittal striatum. In addition, increased radial diffusivity was found in the left corpus callosum.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Our findings highlighted that white matter abnormalities were present by the time of remission of first\u2010episode mania. The widespread occurrence of these white matter abnormalities both in first\u2010episode mania and chronic bipolar disorder suggested that disruption of white matter cortical\u2010subcortical networks as well as projection, associative, and commissural tracts is a hallmark of the illness.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2010.00829.x","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T21:01:15Z","timestamp":1277154075000},"page":"383-389","source":"Crossref","is-referenced-by-count":48,"title":["Cortical and subcortical white matter abnormalities in adults with remitted first\u2010episode mania revealed by Tract\u2010Based Spatial 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