{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:21:17Z","timestamp":1791062477740,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2011,10,21]],"date-time":"2011-10-21T00:00:00Z","timestamp":1319155200000},"content-version":"vor","delay-in-days":81,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>Backlund L, Nikamo P, Sudic Hukic D, R\u00f6mer EK I, Tr\u00e4skman\u2010Bendz L, Land\u00e9n M, Edman G, Schalling M, Fris\u00e9n L, \u00d6sby U. Cognitive manic symptoms associated with the <jats:italic>P2RX7<\/jats:italic> gene in bipolar disorder. Bipolar Disord 2011: 13: 500\u2013508. \u00a9 2011 The Authors. Journal compilation \u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> Several genetic loci have been suggested to be associated with bipolar disorder but results have been inconsistent. Studying associations between bipolar symptoms and candidate genes may better expose this relationship. Here we investigate the association between bipolar key symptoms and the <jats:italic>P2RX7<\/jats:italic> gene.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Key symptoms of mania were rated in two sets of medicated bipolar disorder patients (n\u2003=\u2003171 and n\u2003=\u2003475) at two specialized outpatient clinics for affective disorders and three regular psychiatric outpatient units in Sweden. The relationships between all manic symptoms according to DSM\u2010IV were entered in a principal component analysis. We used a case\u2013case model to reduce the genetic heterogeneity and tested associations between four factors related to manic symptoms and their association to four single nucleotide polymorphisms in the <jats:italic>P2RX7<\/jats:italic> gene.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The combination of the cognitive symptoms, <jats:italic>distractibility<\/jats:italic>, <jats:italic>talkativeness<\/jats:italic>, and <jats:italic>thought disorder<\/jats:italic> was significantly associated with rs1718119 in the <jats:italic>P2RX7<\/jats:italic> gene in Set 1 [odds ratio (OR) = 1.78; p\u2003=\u20030.011]. The association was re\u2010tested in the second set (OR = 1.42; p\u2003=\u20030.009). In the total sample, the association was even stronger (OR = 1.49; p\u2003&lt;\u20030.001). None of the other factors was associated with the <jats:italic>P2RX7<\/jats:italic> gene. Within the first factor, the distractibility symptom accounted for a significant portion of the association to rs1718119 (p\u2003=\u20030.016).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> There is an association between specific symptoms of bipolar disorder and the <jats:italic>P2RX7<\/jats:italic> gene. This finding may open up new approaches to elucidating the neurobiology behind bipolar symptoms.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2011.00952.x","type":"journal-article","created":{"date-parts":[[2011,10,21]],"date-time":"2011-10-21T14:50:32Z","timestamp":1319208632000},"page":"500-508","source":"Crossref","is-referenced-by-count":40,"title":["Cognitive manic symptoms associated with the <i>P2RX7<\/i> gene in bipolar disorder"],"prefix":"10.1111","volume":"13","author":[{"given":"Lena","family":"Backlund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernilla","family":"Nikamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dzana Sudic","family":"Hukic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger 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