{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T20:11:09Z","timestamp":1774987869678,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T00:00:00Z","timestamp":1321315200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>Rosa AR, Reinares M, Amann B, Popovic D, Franco C, Comes M, Torrent C, Bonn\u00edn CM, Sol\u00e9 B, Valent\u00ed M, Salamero M, Kapczinski F, Vieta E. Six\u2010month functional outcome of a bipolar disorder cohort in the context of a specialized\u2010care program. Bipolar Disord 2011: 13: 679\u2013686. \u00a9 2011 The Authors. Journal compilation \u00a9 2011 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> A marked disparity between functional recovery and symptomatic improvement has been demonstrated in bipolar disorder. However, most of the previous studies have been conducted in the United States, and there is little prospective research from Europe on this topic. The main objective of the present six\u2010month follow\u2010up study was to assess functioning in a sample of Spanish bipolar disorder patients following an acute episode or subsyndromal state. Additionally, we also evaluated the sensitivity to change of the Functioning Assessment Short Test (FAST).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 97 bipolar disorder patients with syndromal (n\u2003=\u200359) or subsyndromal (n\u2003=\u200338) symptoms were evaluated using the 17\u2010item Hamilton Depression Rating Scale and Young Mania Rating Scale. The FAST was the primary measure to assess multiple areas of psychosocial functioning. Functioning was evaluated at four different time periods: baseline, 21\u2003days, three months, and six months.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A significant improvement in global functioning was found in the whole sample over the six\u2010month period, as indicated by a reduction of FAST total score (mean \u00b1 standard deviation) from 39.97\u2003\u00b1\u200315.10 to 30.65\u2003\u00b1\u200316.93 (<jats:italic>F\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>36.104, p\u2003=\u20030.0001). This was also evident in all areas of functioning studied. However, only 26.4% of remitted patients (n\u2003=\u200342) achieved functional recovery, while 79.6% of the total sample (N\u2003=\u200397) experienced clinical remission of acute symptoms.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Although many patients presented syndromal recovery, only a minority of them achieved favorable functioning in multiple areas, even after specialized mental health care. Furthermore, the FAST scale was sensitive to detect minimal changes in functioning in both short (21\u2003days) and long (6\u2003months) periods, which may be relevant to the use of this scale in clinical trials.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2011.00964.x","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T11:04:36Z","timestamp":1321441476000},"page":"679-686","source":"Crossref","is-referenced-by-count":63,"title":["Six\u2010month functional outcome of a bipolar disorder cohort in the context of a specialized\u2010care program"],"prefix":"10.1111","volume":"13","author":[{"given":"Adriane 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