{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:21:21Z","timestamp":1792077681920,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,2,13]],"date-time":"2012-02-13T00:00:00Z","timestamp":1329091200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>IsHak WW, Brown K, Aye SS, Kahloon M, Mobaraki S, Hanna R. Health\u2010related quality of life in bipolar disorder. \u2028Bipolar Disord 2012: 14: 6\u201318. \u00a9 2012 The Authors. \u2028Journal compilation \u00a9 2012 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> Health\u2010related quality of life (HRQOL) refers to an individual\u2019s overall sense of wellbeing, and subjective physical, psychological, and social functioning. HRQOL is significantly affected in patients with bipolar disorder (BD), a chronic affective disorder characterized by mood fluctuations, sleep and cognitive impairment, and impact on inter\u2010personal relationships, all of which contribute to HRQOL impairment. This article reviews the relevant literature on the potential causes and magnitude of HRQOL impairment in BD and role of treatment interventions in restoring HRQOL in this patient population.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A systematic database search was conducted using Medline, Cochrane Database of Systematic Reviews, and PsycINFO from 1959 to 2010 with the key words: <jats:italic>bipolar disorder, mania, quality of life,<\/jats:italic> and <jats:italic>wellbeing health\u2010related quality of life<\/jats:italic>. A total of 52 studies were initially identified, leading to the selection of 30 studies that focused on measurement of quality of life in adult population.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> While there is no one standard assessment of HRQOL, most measures incorporate a broad range of questions regarding the patient\u2019s own valuation of their physical, psychological, and social wellbeing. Three main findings are highlighted: (i) BD results in impairment of HRQOL compared to healthy individuals and variable negative impact as compared to other chronic psychiatric and medical conditions; (ii) comorbidities of BD have a further multi\u2010factorial negative impact on HRQOL; and (iii) various pharmacological and non\u2010pharmacological treatment modalities have a positive or equivocal effect on HRQOL in BD.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> HRQOL is significantly adversely affected in BD patients. Additionally, the presence of comorbid conditions highly prevalent in BD further decreases HRQOL for these patients. In spite of these factors, this review offers renewed hope as several treatment regimens correlate with higher post\u2010intervention HRQOL scores.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2011.00969.x","type":"journal-article","created":{"date-parts":[[2012,2,13]],"date-time":"2012-02-13T15:24:42Z","timestamp":1329146682000},"page":"6-18","source":"Crossref","is-referenced-by-count":101,"title":["Health\u2010related quality of life in bipolar disorder"],"prefix":"10.1111","volume":"14","author":[{"given":"Waguih William","family":"IsHak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San San","family":"Aye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kahloon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakiba","family":"Mobaraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,13]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(89)90005-6"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(95)00112-K"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-2988-6_2"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.36.8.585"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00203-2"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.3.379"},{"key":"e_1_2_10_8_2","first-page":"652","article-title":"Symptoms and functioning of patients with bipolar disorder six months after hospitalization","volume":"39","author":"Dion GL","year":"1988","journal-title":"Hosp Community Psychiatry"},{"key":"e_1_2_10_9_2","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1001\/jama.1995.03530190025030","article-title":"Health\u2010related quality of life in primary care patients with mental disorders. 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