{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:51:28Z","timestamp":1787961088909,"version":"build-2784847793"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T00:00:00Z","timestamp":1331769600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>Swartz HA, Frank E, Cheng Y. A randomized pilot study of psychotherapy and quetiapine for the acute treatment of bipolar II depression. Bipolar Disord 2012: 14: 211\u2013216. \u00a9 2012 The Authors. Journal compilation \u00a9 2012 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> The differential roles of psychotherapy and pharmacotherapy in the management of bipolar (BP) II depression are unknown. As a first step toward exploring this issue, we conducted a pilot study to evaluate the feasibility and acceptability of comparing a BP\u2010specific psychotherapy [Interpersonal and Social Rhythm Therapy (IPSRT)] to quetiapine as treatments for BP\u2010II depression.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Unmedicated individuals (n\u2003=\u200325) meeting DSM\u2010IV criteria for BP\u2010II disorder, currently depressed, were randomly assigned to weekly sessions of IPSRT (n\u2003=\u200314) or quetiapine (n\u2003=\u200311), flexibly dosed from 25\u2013300\u2003mg. Participants were assessed with weekly measures of mood and followed for 12\u2003weeks. Treatment preference was queried prior to randomization.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Using mixed effects models, both groups showed significant declines in the 25\u2010item Hamilton Rating Scale for Depression [<jats:italic>F<\/jats:italic>(1,21) = 44, p\u2003&lt;\u20030.0001] and Young Mania Rating Scale [<jats:italic>F<\/jats:italic>(1,21) = 20, p\u2003=\u20030.0002] scores over time but no group\u2010by\u2010time interactions. Dropout rates were 21% (n\u2003=\u20033) and 27% (n\u2003=\u20033) in the IPSRT and quetiapine groups, respectively. Overall response rates (defined as \u2265 50% reduction in depression scores without an increase in mania scores) were 29% (n\u2003=\u20034) in the IPSRT group and 27% (n\u2003=\u20033) in the quetiapine group. Measures of treatment satisfaction were high in both groups. Treatment preference was not associated with outcomes.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Outcomes in participants with BP\u2010II depression assigned to IPSRT monotherapy or quetiapine did not differ over 12\u2003weeks in this small study. Follow\u2010up trials should examine characteristics that predict differential response to psychotherapy and pharmacotherapy.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2012.00988.x","type":"journal-article","created":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T13:52:20Z","timestamp":1331819540000},"page":"211-216","source":"Crossref","is-referenced-by-count":56,"title":["A randomized pilot study of psychotherapy and quetiapine for the acute treatment of bipolar II depression"],"prefix":"10.1111","volume":"14","author":[{"given":"Holly 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