{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:14:25Z","timestamp":1789391665381,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T00:00:00Z","timestamp":1331769600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>Cerullo MA, Fleck DE, Eliassen JC, Smith MS, DelBello MP, Adler CM, Strakowski SM. A longitudinal functional connectivity analysis of the amygdala in bipolar I disorder across mood states. Bipolar Disord 2012: 14: 175\u2013184. \u00a9 2012 The Authors. Journal compilation \u00a9 2012 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> Bipolar I disorder is characterized by affective symptoms varying between depression and mania. The specific neurophysiology responsible for depression in bipolar I disorder is unknown but previous neuroimaging studies suggest impairments in corticolimbic regions that are responsible for regulating emotion. The amygdala seems to play a central role in this network and is responsible for appraisal of emotional stimuli. To further understand the role of the amygdala in the generation of mood symptoms, we used functional magnetic resonance imaging (fMRI) to examine a group of patients with bipolar I disorder longitudinally.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> fMRI was used to study regional brain activation in 15 bipolar I disorder patients followed for up to one year. Patients received an fMRI scan during an initial manic episode and a subsequent depressive episode. During the scans, patients performed an attentional task that incorporated emotional pictures. Fifteen healthy comparison subjects were also scanned at baseline and then at four months. Whole\u2010brain functional connectivity analysis was performed using the left and right amygdala as seed regions.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Significant changes in amygdala functional connectivity were found between the manic and depressed phases of illness. The right amygdala was significantly more positively correlated with the left inferior frontal gyrus during mania and with the right insula during depression. There were no significant differences in left amygdala correlations across mood states in the bipolar I disorder group.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In the transition from a manic\/mixed episode to a depressive episode, subjects with bipolar I disorder showed unique changes in cortical\u2013amygdala functional connectivity. Increased connectivity between the insula and right amygdala may generate excessive positive feedback, in that both of these regions are involved in the appraisal of emotional stimuli. Increased correlation between the right amygdala and the inferior frontal gyrus in mania is consistent with previous findings of decreased prefrontal modulation of limbic regions in mania. These differences in connectivity may represent neurofunctional markers of mood state as they occurred in the same individuals across manic and depressive episodes.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2012.01002.x","type":"journal-article","created":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T13:52:20Z","timestamp":1331819540000},"page":"175-184","source":"Crossref","is-referenced-by-count":81,"title":["A longitudinal functional connectivity analysis of the amygdala in bipolar I disorder across mood states"],"prefix":"10.1111","volume":"14","author":[{"given":"Michael A","family":"Cerullo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E","family":"Fleck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C","family":"Eliassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt S","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa P","family":"DelBello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb M","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M","family":"Strakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,15]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001585"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900020800"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/09540260902962107"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5215.2009.00414.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.09.019"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.23.1.155"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09275.x"},{"key":"e_1_2_7_9_2","first-page":"315","article-title":"The limbic system: an anatomic, phylogenetic, and clinical perspective","volume":"9","author":"Mega M","year":"2000","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00332-4"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.01.008"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.06.008"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145708008973"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09081235"},{"key":"e_1_2_7_15_2","volume-title":"Structured Clinical Interview for DSM\u2010IV Axis I Disorders\u2010 Patient Edition (SCID\u2010I\/P)","author":"First MB","year":"1995"},{"key":"e_1_2_7_16_2","volume-title":"Washington University in St. Louis Kiddie and Young Adult Schedule for Affective Disorders and Schizophrenia (WASH\u2010U\u2010KSADS)","author":"Geller B","year":"1996"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688639108405109"},{"key":"e_1_2_7_20_2","volume-title":"Wechsler Abbreviated Scale of Intelligence","author":"Wechsler D","year":"1999"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2006.00245.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340305"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1109\/42.929619"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182176499"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199912)42:6<1014::AID-MRM4>3.0.CO;2-F"},{"key":"e_1_2_7_26_2","volume-title":"Co\u2010planar Stereotaxic Atlas of the Human Brain: 3\u2010Dimensional Proportional System: An Approach To Cerebral Imaging","author":"Talairach J","year":"1988"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.4"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460020107"},{"key":"e_1_2_7_29_2","first-page":"1636","article-title":"Mapping functionally related regions of brain with functional connectivity MR imaging","volume":"21","author":"Cordes D","year":"2000","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_7_30_2","first-page":"1326","article-title":"Frequencies contributing to functional connectivity in the cerebral cortex in \u2018resting\u2010state\u2019 data","volume":"22","author":"Cordes D","year":"2001","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0763"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.12.042"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.09.036"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.09.028"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20324"},{"key":"e_1_2_7_37_2","first-page":"423","article-title":"Type I and type II error concerns in fMRI research: re\u2010balancing the scale","volume":"4","author":"Lieberman M","year":"2009","journal-title":"SCAN"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200410250-00009"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.08.027"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/39051"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199910000-00002"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000220132.32091.9f"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.18.2.212"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2010.02.010"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.04.015"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2007.04.007"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.04.002"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-5618.2012.01002.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-5618.2012.01002.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T05:49:24Z","timestamp":1698731364000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-5618.2012.01002.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1399-5618.2012.01002.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-5618.2012.01002.x","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}