{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:25:49Z","timestamp":1792589149080,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T00:00:00Z","timestamp":1335916800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Barbosa IG, Vale TC, de Macedo DL, Gomez RS, Teixeira AL. Neurosyphilis presenting as mania. Bipolar Disord 2012: 14: 309\u2013312. \u00a9 2012 The Authors. Journal compilation \u00a9 2012 John Wiley &amp; Sons A\/S.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> General paresis of the insane is a late and severe form of neurosyphilis characterized by nonspecific neuropsychiatric symptoms. There are a limited number of case reports of mood disorders presenting in neurosyphilis, with depressive illness being the most common.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We performed a literature review of case reports of secondary bipolar disorder induced by syphilitic infection.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Herein reported is a case of a 53\u2010year\u2010old woman who initially presented with symptoms of mania and depression, mimicking bipolar disorder, but was subsequently diagnosed with general paresis of the insane.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The present case report emphasizes that if a substantial delay occurs in syphilis diagnosis and management, the patient may have a very poor prognosis.<\/jats:p>","DOI":"10.1111\/j.1399-5618.2012.01007.x","type":"journal-article","created":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T11:04:25Z","timestamp":1335956665000},"page":"309-312","source":"Crossref","is-referenced-by-count":18,"title":["Neurosyphilis presenting as mania"],"prefix":"10.1111","volume":"14","author":[{"given":"Izabela Guimar\u00e3es","family":"Barbosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Cardoso","family":"Vale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Lino","family":"de Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Santiago","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio L\u00facio","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,2]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0707"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822006000400016"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000327526.71683.b7"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.115.518.31"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.137.6.741"},{"key":"e_1_2_8_7_2","first-page":"338","article-title":"Reversible neurosyphilis presenting as chronic mania","volume":"43","author":"Hoffman BF","year":"1982","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1982.04290060075016"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.155.4.559"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(90)72142-1"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v62n0612e"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108093585"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0b013e31817781c9"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-000-0030-6"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0206"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.06.009"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.04.012"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-009-0019-1"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.42.6.453"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-5618.2012.01007.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-5618.2012.01007.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:29:34Z","timestamp":1698712174000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-5618.2012.01007.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1399-5618.2012.01007.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-5618.2012.01007.x","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}